Threonine manganese as well as preparation method and application thereof

Abstract

The invention discloses a threonine chelate named threonine manganese, a preparation method thereof comprises the following steps that: sulfate of manganese or crystalline hydrate of sulfate of manganese having a molar ratio of (0.5-1.1):2 is mixed with threonine aqueous solution, followed by reaction at pH value of 4-8 at the temperature of 60-100 DEG C under the protection of inert gases, 0.5-6 hours later, reaction product is obtained; the reaction product is subjected to vacuum concentration or is extracted by an organic solvent, and is then dried and crushed to obtain threonine manganese finished product. The threonine manganese of the invention can serve as an additive of animal feed in order to effectively promote growth of animals, enhance resistance of animals and raise utilization rate of feed.

Description

technical field

[0001] The invention relates to a feed additive and a preparation method thereof, in particular to an amino acid chelate compound, a preparation method and application thereof. Background technique

[0002] Threonine is an important nutritional enhancer, which can strengthen the nutrition of grains, cakes, dairy products, etc. Threonine, like tryptophan, also has the functions of restoring human fatigue and promoting growth and development. In medicine, because the structure of threonine contains hydroxyl groups, it has a water-holding effect on human skin. After combining with oligosaccharide chains, it can play an important role in protecting cell membranes; threonine can also promote phospholipid synthesis and fatty acid oxidation in the body , and its preparation has medicinal effects such as promoting human growth and anti-fatty liver, and is often used as a component of compound amino acid infusion. At the same time, threonine is also the basic raw ma...

Examples

Embodiment 1

[0026] A manganese threonine finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve, replace the air in the reactor, then under the protection of nitrogen, take 41.75g ​​of threonine and put it into a tank containing 100g of reaction water. Fully stir in the reaction kettle, then drop 29.62g of manganese sulfate monohydrate, adjust the pH value of the reaction mixture to 5.8 with 13.88g of sodium hydroxide at a temperature of 93°C, react for 1.5h under normal pressure, and then use the reaction product Extract with ethanol for 15 minutes, and the volume ratio of ethanol to reaction product is 8:1. The precipitate after extraction is dried at 100° C. in a flash, and crushed to prepare the finished product of manganese threonine.

[0027] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the reaction product, and the values ​​are all above 80%.

[0028] The...

Embodiment 2

[0039] A manganese threonine finished product of the present invention is prepared through the following steps: first open the nitrogen valve, replace the air in the reactor, and under the protection of nitrogen, take 348Kg threonine and put it into the reaction tank containing 1000kg of reaction water. Fully stir in the kettle, then put 247Kg of manganese sulfate monohydrate, maintain the pH value of the reaction mixture at 93°C with 115Kg of sodium hydroxide, react for 2 hours under normal pressure, and then send the reaction product to the concentration tank , at 0.5kgf / cm 2 Vacuum concentration at a temperature of 90°C for 45 minutes. After the product is viscous, the concentrate is fed into a tray, flashed and dried at 120°C, and crushed to prepare the finished product of manganese threonine.

[0040] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the reaction product, and the values ​​are all above 80%. ...

technical field

[0001] The invention relates to a feed additive and a preparation method thereof, in particular to an amino acid chelate compound, a preparation method and application thereof. Background technique

[0002] Threonine is an important nutritional enhancer, which can strengthen the nutrition of grains, cakes, dairy products, etc. Threonine, like tryptophan, also has the functions of restoring human fatigue and promoting growth and development. In medicine, because the structure of threonine contains hydroxyl groups, it has a water-holding effect on human skin. After combining with oligosaccharide chains, it can play an important role in protecting cell membranes; threonine can also promote phospholipid synthesis and fatty acid oxidation in the body , and its preparation has medicinal effects such as promoting human growth and anti-fatty liver, and is often used as a component of compound amino acid infusion. At the same time, threonine is also the basic raw ma...

Examples

Embodiment 1

[0026] A manganese threonine finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve, replace the air in the reactor, then under the protection of nitrogen, take 41.75g ​​of threonine and put it into a tank containing 100g of reaction water. Fully stir in the reaction kettle, then drop 29.62g of manganese sulfate monohydrate, adjust the pH value of the reaction mixture to 5.8 with 13.88g of sodium hydroxide at a temperature of 93°C, react for 1.5h under normal pressure, and then use the reaction product Extract with ethanol for 15 minutes, and the volume ratio of ethanol to reaction product is 8:1. The precipitate after extraction is dried at 100° C. in a flash, and crushed to prepare the finished product of manganese threonine.

[0027] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the reaction product, and the values ​​are all above 80%.

[0028] The...

Embodiment 2

[0039] A manganese threonine finished product of the present invention is prepared through the following steps: first open the nitrogen valve, replace the air in the reactor, and under the protection of nitrogen, take 348Kg threonine and put it into the reaction tank containing 1000kg of reaction water. Fully stir in the kettle, then put 247Kg of manganese sulfate monohydrate, maintain the pH value of the reaction mixture at 93°C with 115Kg of sodium hydroxide, react for 2 hours under normal pressure, and then send the reaction product to the concentration tank , at 0.5kgf / cm 2 Vacuum concentration at a temperature of 90°C for 45 minutes. After the product is viscous, the concentrate is fed into a tray, flashed and dried at 120°C, and crushed to prepare the finished product of manganese threonine.

[0040] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the reaction product, and the values ​​are all above 80%. ...

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