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Wiregrid monitor device

A technology of equipment and illuminants, applied in the field of biosensors, can solve the problems of sensor accuracy and surface specificity reduction

Active Publication Date: 2012-01-04
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This limited background suppression ultimately leads to a reduction in the accuracy and surface-specificity of the sensor

Method used

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Embodiment Construction

[0028] Several embodiments of the present invention will be described below with reference to the accompanying drawings. These embodiments are described in order to enable others skilled in the art to practice the invention and to disclose the best mode. However, such embodiments do not limit the invention. Furthermore, other combinations of different features are possible within the scope of the invention.

[0029] Biosensors according to embodiments described below may include analytes disposed in apertures defined by a material that is non-transparent to at least one of excitation light and luminescence, typical examples being aluminum, gold, silver, chromium , having a first in-plane dimension below the diffraction limit of the excitation light in the medium within the aperture and a second in-plane dimension above the diffraction limit of the excitation light in the medium within the aperture. In-plane dimensions refer to dimensions in a plane parallel to the substrate....

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Abstract

A device for monitoring radiation emitted by luminophores present in an analyte fluid of a wiregrid biosensor. The monitoring device comprises a non-polarized light source (41) for illuminating the wiregrid biosensor for exciting fluorescent labels arranged in the analyte fluid of said biosensor. A detector (71) detects radiation emitted by the labels after excitation. A polarizing filter (53) isarranged in between the transparent substrate and the detector for suppression of background emission radiation from labels positioned outside aperatures in the wiregrid, in the analyte fluid.

Description

technical field [0001] The present invention relates to the field of biosensors, and more particularly, to sub-diffraction-limited biosensors. Background technique [0002] Biosensor technology is well known in the art. [0003] US Patent Application No. 2003 / 0174992 discloses a method and apparatus for providing a zero-mode waveguide comprising an analyte excited by electromagnetic radiation for analysis of the analyte. [0004] WO2006 / 136991 entitled "Luminescence sensors using sub-wavelength apertures or slits" discloses a biosensor with sub-wavelength spatial resolution. [0005] WO2007 / 072415 entitled "Luminiscence sensor operating in reflection mode" discloses a method for detecting fluorescent radiation produced by molecules in an aperture. [0006] Such a biosensor may comprise a non-transparent material disposed on a transparent material substrate and forming at least one aperture for filling said analyte fluid. The apertures have a first in-plane dimension below...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/6452G01N21/648
Inventor D·J·W·克伦德M·M·J·W·范赫彭H·R·斯塔珀特
Owner KONINK PHILIPS ELECTRONICS NV