Nitazoxanide suspension for expelling parasite in livestock body and preparation method thereof

A technology of nitazoxanide and endoparasites, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve the problem of nitazoxanide suspension that has not yet been reported and sold. and other issues to achieve the effect of stable product quality and simple production process

Inactive Publication Date: 2009-12-23
QINGDAO VLAND BIOTECH INC +2
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[0008] The nitazoxanide suspension for repelling and curing livestock endoparasites of the present invention is characterized in that its components and mass percentage ranges are 3-5% of nitazoxanide, 0.2%-0.5% of xanthan gum, carbomer 0.2%-0.6%, citric acid 0.3%-0.6%, trisodium citrate 0.15-0.3%, stabilizer 0.15-0.3%, flavoring agent 4%-9%, and the rest is water. During preparation, xanthan gum and carbomer are added with water to make a glue solution, placed in an emulsifier, then added with citric acid, trisodium citrate, stabilizer, nitazoxanide, and flavoring agent for shearing.

[0009] The preparation of nitazoxanide into a suspension mainly considers the following aspects: first, nitazoxanide is a hydrophobic drug and is not suitable for making water-soluble preparations; secondly, combining the pharmacokinetic properties of nitazoxanide , that is, the metabolism in the body is extremely fast, and the elimination half-life of its active metabolites is not long (1.03-1...

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Abstract

The invention relates to a nitazoxanide suspension for expelling parasite in livestock body, comprising the following components by weight percent: 3-5 percent of nitazoxanide, 0.2-0.5 percent of xanthan gum, 0.2-0.6 percent of Carbomer, 0.3-0.6 percent of citric acid, 0.15-0.3 percent of trisodium citrate, 0.15-0.3 percent of stabilizing agent, 4-9 percent of flavoring agent and the balance of water. During preparation, water is added in the xanthan gum and Carbomer to prepare a glue solution; the glue solution is placed in an emulsifier, and then, the citric acid, trisodium citrate, stabilizing agent, nitazoxanide and flavoring agent are added for shearing. The invention has simple producing process and stable product quality, can be stored for a long time, needs no preparation in use, can be produced in large quantities, and can provide the herdsmen in pasturing areas and stockmen to prevent and treat parasite for herd and sheep flock.

Description

technical field [0001] The invention relates to a suspension of nitazoxanide for expelling parasites in livestock and a preparation method thereof. Background technique [0002] There are many kinds of parasitic diseases and they are widely distributed. They are very common and serious diseases of livestock. They seriously affect the production of meat, milk and eggs, the quality of fur and the working ability of draft animals. Some zoonotic parasitic diseases also directly harm human health. Therefore, parasitic diseases not only hinder the development of animal husbandry and cause huge economic losses, but also are the most common and serious public health problems. In the past 10 years, due to insufficient investment in science and technology and funds, there are not many new technologies suitable for production, and there are basically no major breakthroughs and innovations in parasitic disease control technology. Chemical control is still the leading control method at ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/426A61K47/36A61P33/00A61P33/10
Inventor 郝智慧刘元元单虎张瑞丽贾德强
Owner QINGDAO VLAND BIOTECH INC
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