Nakedflower beautyberry extract as well as preparation method, preparation and application thereof

A technology of violacea nudiflora and extracts, applied in the directions of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve the problems of single, simple and rough process, unresearched rationality, etc., and achieves high yield and simple preparation process. Effect

Active Publication Date: 2010-01-13
HAINAN JIUZHITANG PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are naked flower purple bead tablets, naked flower purple bead suppository, naked flower purple bead mixture, etc. The current process is to decoct twice in water, then concentrate, filter, and dry into a dry extract. The process is simple and rough, but it has been used nearly For 30 ye

Method used

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  • Nakedflower beautyberry extract as well as preparation method, preparation and application thereof
  • Nakedflower beautyberry extract as well as preparation method, preparation and application thereof
  • Nakedflower beautyberry extract as well as preparation method, preparation and application thereof

Examples

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Example Embodiment

[0015] Example 1

[0016] Take 100kg of the herbal medicine, add 1500kg of water, soak for 30 minutes, heat and boil for 120 minutes, pour out the decoction, and decoct the medicinal residue twice, add 1500kg of water each time, boil for 60 minutes, combine the three decoctions, filter, and the filtrate passes through The specific surface area is 350~450m 2 JD-1(WLD) polystyrene macroporous adsorption resin column with skeleton density of 1~1.2g / ml, average pore diameter of 35~65nm and void ratio of 60~68%, the diameter of the resin column is high The ratio was 1:5, the effluent was discarded, the column was washed with 5 column volumes of water, the washing solution was discarded, and 10% ethanol was used to elute until no flavonoids were detected in the eluent. The eluate was collected, ethanol was recovered, and concentrated under reduced pressure to a relative density of 1.2, freeze-dried, and the extract was obtained by testing and sub-packing. The polystyrene macropor...

Example Embodiment

[0018] Embodiment 2

[0019] Take 100kg of the herbal medicine, dilute 1000kg of alcohol, soak for 50 minutes, heat and boil for 90 minutes, pour out the decoction, and decoct the medicinal residues twice, add 1500kg of water each time, boil for 90 minutes, combine the three decoctions, filter, Filtrate passing specific surface area is 350 ~ 450m 2 D101 polystyrene macroporous adsorption resin column with skeleton density of 1-1.2g / ml, average pore diameter of 35-65nm, and void ratio of 60-68%, the diameter-height ratio of the resin column is 1:7 , discard the effluent, wash the column with 4 column volumes of water, discard the washing solution, and elute with 50% ethanol until no flavonoids are detected in the eluent. The eluate was collected, ethanol was recovered, concentrated under reduced pressure to a relative density of 1.1, freeze-dried, and the extract was obtained by testing and sub-packing. The polystyrene macroporous adsorption resin column was washed with 10%...

Example Embodiment

[0021] Embodiment 3

[0022] Take 100kg of the herbal medicine, add 2000kg of dilute ketone, soak for 40 minutes, heat and boil for 60 minutes, take out the decoction, and decoct the dregs for 2 times, add 1000kg of water each time, boil for 60 minutes, combine the three decoctions, filter, and filtrate Through the specific surface area of ​​350 ~ 450m 2 AB-8 polystyrene macroporous adsorption resin column with a skeleton density of 1-1.2g / ml, an average pore diameter of 35-65nm, and a porosity of 60-68%, the diameter-height ratio of the resin column is 1 : 10, discard the effluent, wash the column with 6 column volumes of water, discard the washing solution, and elute with 90% ethanol until no flavonoids are detected in the eluent. The eluate was collected, ethanol was recovered, and concentrated under reduced pressure to a relative density of 1.08, freeze-dried, and the extract was obtained by testing and sub-packing. The polystyrene macroporous adsorption resin column w...

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Abstract

The invention relates to a nakedflower beautyberry extract as well as a preparation method, a preparation and an application thereof. The nakedflower beautyberry extract is an extract which is extracted from nakedflower beautyberry leaves and contains a nakedflower beautyberry total flavonoid compound and a tannide class compound. The extract is obtained by the steps of extracting the nakedflower beautyberry leaves by water, diluted alcohol or diluted ketone and carrying out macroporous adsorptive resin column chromatography purification on an extracting solution after being concentrated. The nakedflower beautyberry extract has high purity and has the functions of bacteriostasis, hemostasis, pain relieving and convergence.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to an extract of Auranthus nudiflora and its preparation method, preparation and application. Background technique [0002] Callicarpanudiflora (Callicarpanudiflora Hook.exArn.) is a plant of the genus Verbenaceae (Verbenaceae). It is mainly produced in Hainan, my country. It is an authentic medicinal material in Hainan, and it is also distributed in Guangdong and Guangxi. Foreign countries are mainly distributed in India, Vietnam and Malaysia. Its roots and leaves can be used as medicine. It has the functions of antibacterial and hemostasis, anti-inflammatory and detoxification, dispelling stasis and swelling, and dispelling wind and dampness. , burns and traumatic bleeding. [0003] At present, there are naked flower purple bead tablets, naked flower purple bead suppository, naked flower purple bead mixture, etc. The current process is to decoct twice in wate...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P7/04A61P31/02A61P29/00
Inventor 宁云山关继峰严冬兰
Owner HAINAN JIUZHITANG PHARMACY
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