Calcium acetate tablet and preparation method thereof

A technology of calcium acetate and magnesium stearate, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, anhydride/acid/halide active ingredients, etc. The problem of large dosage, etc., achieves the effect of safe and effective treatment of hyperphosphatemia, shortened disintegration time and convenient administration.

Active Publication Date: 2010-01-20
KUNMING BANGYU PHARMA
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the small size of calcium acetate granules, 2 to 5 bags of 600mg/bag are needed to achieve the effect of reducing blood phosphorus, which is very inconvenient to eat.
Moreover, the existing calcium acet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium acetate tablet and preparation method thereof
  • Calcium acetate tablet and preparation method thereof
  • Calcium acetate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Calcium acetate (C 4 h 6 CaO 4 ) 667g (91.36%)

[0029] Sodium Starch Carboxymethyl 35g (4.75%)

[0030] Crospovidone 25g (3.39%)

[0031] Magnesium Stearate 10g (1.36%)

[0032]

[0033] Makes 1000 pieces

[0034] Preparation method:

[0035] a. Calcium acetate is pulverized through a 60-mesh sieve for subsequent use;

[0036] b. Prepare 50% ethanol for subsequent use;

[0037] c. Take the calcium acetate of recipe quantity and put in the fast mixing granulator, add 50% ethanol in right amount, make soft material, cross 10 mesh sieves and granulate;

[0038] d. Set the drying temperature to 50°C, and dry the wet granules in a hot air circulation oven or common drying equipment until the moisture content is lower than 5%;

[0039] e. Sieve the dry granules through 16 sieves, add sodium starch glycolate, crospovidone and magnesium stearate, and mix in a mixer for 7 minutes;

[0040] f. Measure the main drug co...

Embodiment 2

[0043] Calcium acetate (C 4 h 6 CaO 4 ) 667g (95.68%)

[0044] Sodium starch glycolate 14.9g (1.92%)

[0045] Crospovidone 14.9g (1.92%)

[0046] Magnesium Stearate 3.7g (0.48%)

[0047]

[0048] Makes 1000 pieces

[0049] Preparation method:

[0050] a. Calcium acetate is pulverized and sieved through 80 sieves for subsequent use;

[0051] b. Prepare 80% ethanol for subsequent use;

[0052] c. take the calcium acetate of recipe quantity and put in the fast mixing granulator, add 80% ethanol in right amount, make soft material, cross 16 mesh sieves and granulate;

[0053] d. Set the drying temperature to 75°C, and dry the wet granules in a hot air circulation oven or common drying equipment until the moisture content is lower than 5%;

[0054] e. Pass the dry granules through a 16-mesh sieve for granulation, add sodium starch glycolate, crospovidone and magnesium stearate, and mix in a mixer for 10 minutes;

[005...

Embodiment 3

[0058] Calcium acetate (C 4 h 6 CaO 4 ) 667g (96.95%)

[0059] Sodium carboxymethyl starch 8g (1.16%)

[0060] Crospovidone 12g (1.74%)

[0061] Magnesium Stearate 1g (0.145%)

[0062]

[0063] Makes 1000 pieces

[0064] Preparation method:

[0065] a. Calcium acetate is pulverized through a 100-mesh sieve for subsequent use;

[0066]b. Prepare 90% ethanol for subsequent use;

[0067] c. take the calcium acetate of recipe quantity and put in the fast mixing granulator, add 90% ethanol in right amount, make soft material, cross 20 mesh sieves and granulate;

[0068] d. Set the drying temperature to 90°C, and dry the wet granules in a hot air circulation oven or common drying equipment until the moisture content is lower than 5%;

[0069] e. Sieve the dry granules through a 20-mesh sieve, add sodium starch glycolate, crospovidone and magnesium stearate, and mix in a mixer for 15 minutes;

[0070] f. Measure the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a calcium acetate tablet which relates to a medicine manufacturing technique, in particular to a calcium acetate tablet and a preparation method thereof. The calcium acetate tablet consists of the following components in percentage by weight: 90-97 percent of calcium acetate, 1-8 percent of carboxyrnethyl starch sodium, 1-8 percent of polyvinylpolypyrrolidone and 0.1-5 percent of magnesium stearate. The calcium acetate tablet has small dosage of adjuvant materials, moderate tablet size, convenient administration and shortened disintegration time, and can be used for safely and effectively curing hyperphosphatemia.

Description

technical field [0001] The invention relates to a medicine manufacturing technology, in particular to a calcium acetate tablet and a preparation method thereof. Background technique [0002] Calcium acetate is made by reacting calcium carbonate in animal shells or minerals with acetic acid. It is used as a chelating agent in food additives in the US "Food Chemistry Code FCC", and as a chelating agent in food in my country's "Food Additives Handbook". Antifungal agents, stabilizers, buffers, and flavor enhancers are used in blood and peritoneal dialysis agents in the American and British Pharmacopoeias. In 1998, the United States used calcium acetate as a new drug for the treatment of hyperphosphatemia. In recent years, there have been many studies on hyperphosphatemia and calcium acetate for reducing blood phosphorus. [13-32] , the research results show that calcium acetate is indeed superior to other similar products in terms of the curative effect of reducing blood phosph...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K31/19A61K47/36A61K47/32A61K47/12A61P3/12
Inventor 王冰刘晓凯张永胜普会兰闫红英杜元英
Owner KUNMING BANGYU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap