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Preparation method of water-soluble extract of red sage root

A water-soluble extract, water extraction technology, applied in the field of extraction of active ingredients of natural plants, can solve the problems of low content of active ingredients in extracts, increased purification process steps, insignificant pharmacological effects, etc. The effect of high visibility and loss avoidance

Inactive Publication Date: 2011-01-19
西藏和藤医药发展股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the water-soluble components of Danshen are mainly obtained by traditional methods such as water extraction and alcohol precipitation, but the content of active components in the obtained extract is low, and the pharmacological effects are not obvious
In the traditional method of purifying Danshen extract, one of the active ingredients, Danshensu Sodium, will lose 30% to 50%; Purification, increased purification process steps, complex operation

Method used

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  • Preparation method of water-soluble extract of red sage root
  • Preparation method of water-soluble extract of red sage root
  • Preparation method of water-soluble extract of red sage root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]The preparation method of the salvia miltiorrhiza water-soluble extract of the present embodiment comprises the steps:

[0040] (1) Get 100g of Salvia miltiorrhiza medicinal material, pulverize, after passing through a 10-mesh pharmacopoeia sieve, add 8 times (weight ratio) water to reflux and extract for 1 hour, repeat the extraction of the residue twice, combine the extracts, and concentrate the extracts until the relative density of the medicinal solution is 1.2;

[0041] (2) Add 95% by volume of ethanol to the above-mentioned concentrated extract to carry out alcohol precipitation treatment on the extract, the amount of 95% by volume of ethanol is 70% of the volume of the extract after concentration, filter, and concentrate the filtrate to the relative density of the liquid is 1.2;

[0042] (3) Using 1mol / L hydrochloric acid solution to adjust the pH of the concentrated alcohol solution to 1.0, filter to remove the precipitate, and take the supernatant;

[0043] (4...

Embodiment 2

[0047] The preparation method of the salvia miltiorrhiza water-soluble extract of the present embodiment comprises the steps:

[0048] (1) Take 100 g of Danshen medicinal material, pulverize it, pass through a 20-mesh pharmacopoeia sieve, add 10 times (weight ratio) water to reflux for extraction for 1 hour, repeat the extraction of the residue twice, combine the extracts, and concentrate until the relative density of the medicinal solution is 1.20;

[0049] (2) Add 95% by volume of ethanol to the above-mentioned concentrated extract to carry out alcohol precipitation treatment on the extract, the amount of 95% by volume of ethanol is 75% of the volume of the extract after concentration, filter, and concentrate the filtrate to the relative density of the liquid is 1.2;

[0050] (3) Using 5mol / L hydrochloric acid solution to adjust the pH of the concentrated alcohol solution to 4, filter to remove the precipitate, and take the supernatant;

[0051] (4) Purify the supernatant w...

Embodiment 3

[0054] Embodiment 3 Salvia miltiorrhiza water-soluble extract process comparison

[0055] The salvia miltiorrhiza used in this example is commercially available.

[0056] This embodiment divides contrast group and experimental group:

[0057] In the comparison group, the above-mentioned medicinal material of Danshen was processed by using the existing technology for preparing the water-soluble extract of Danshen, so as to prepare the water-soluble extract of Danshen.

[0058] The experimental group used the preparation method described in Example 1 to process the above-mentioned Danshen medicinal material, thereby preparing a water-soluble extract of Danshen.

[0059] In the prior art, the preparation process of the water-soluble extract of Salvia miltiorrhiza, the steps are as follows:

[0060] The salvia miltiorrhiza medicinal material is pulverized and sieved, and the coarse grain of the medicinal material taken through a 50-mesh medicinal sieve is added with 1.5% by mass...

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Abstract

The invention discloses a preparation method of a water-soluble extract of red sage root, comprising the following steps: treating the red sage root sequentially by water extraction, deposition in alcohol and purification, then carrying out heat treatment on the red sage root under the environment of weak base and finally obtaining the required water-soluble extract of the red sage root by concentration. The operation of purification and then degradation is adopted; purified danshinolic acid B is degraded to obtain tanshinol sodium under an alkaline condition; the content of the tanshinol sodium in the obtained water-soluble extract of the red sage root is from 10% to 50%, the content of protocatechuic acid is from 2% to 10%, and the content of the danshinolic acid is from 3% to 20%. In the invention, only macroporous resin is used for separation and purification with good separation effect and low ointment obtaining rate, and the macroporous resin can be used repeatedly and has low purification cost. The method has simple operation, high process reproduction quality and controllability and more stable proportion of each component in the obtained water-soluble extract of the red sage root, avoids losing the tanshinol sodium in the processes of extraction and separation and is beneficial to industrial production.

Description

technical field [0001] The invention relates to the extraction technology of natural plant active ingredients, in particular to a preparation method of a water-soluble extract of salvia miltiorrhiza. Background technique [0002] The traditional Chinese medicine Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bunge, a perennial herb of the genus Salvia in the family Lamiaceae. As a traditional Chinese medicine, Salvia miltiorrhiza has been used for a long time in my country. It was first recorded in "Shen Nong's Materia Medica", and was listed as top grade. It is recorded in "Materia Medica" and "Compendium of Materia Medica". Salvia miltiorrhiza has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstruation, clearing heart and eliminating troubles, and it is mainly used to treat coronary heart disease, angina pectoris, upset and insomnia, irregular menstruation, amenorrhea and dysmenorrhea. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10A61P25/20A61P15/00A61K125/00
Inventor 钱陈钦梁健登贾珺璋
Owner 西藏和藤医药发展股份有限公司
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