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Rheumatic bone-setting transdermal patch and preparation process thereof

A transdermal patch and preparation technology, which is applied in the field of transdermal patch for rheumatism and traumatic injuries, and can solve problems such as easy contamination, affecting drug efficacy, and poor transdermal patch effect

Inactive Publication Date: 2010-03-03
北京化药科创医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Fengshi Dieda tincture is a liquid preparation, which is easy to lose at the site of application, and the local residence time is short, which is not conducive to the best curative effect of the drug, and it is also inconvenient to use, store and transport
Chinese patent CN1883565A discloses a gel preparation for treating rheumatic joint pain and bruises and sprains. Evenly smear the affected area, but it is easy to contaminate the clothes and quilts, and the clothes and quilts will not be polluted. Moreover, after the quilts are put on, the actual amount applied to the affected area will be reduced, which will affect the efficacy of the drug, and the actual transdermal absorption efficiency of the gel will also decrease. Not good, because after being applied to the affected area, the gel loses water in the air and becomes dry, reducing the drug penetration rate
[0004] The transdermal patch is a kind of easy to carry, and the appropriate prescription configuration can significantly increase the transdermal absorption rate of the drug. However, because the transdermal patch itself has a small drug load, when it is prepared by the process in the standard of Fengshi Dieda Tincture When the active ingredient part of the transdermal patch is used, the effect of the prepared transdermal patch is not good, and the content of active ingredient per unit is obviously smaller

Method used

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  • Rheumatic bone-setting transdermal patch and preparation process thereof
  • Rheumatic bone-setting transdermal patch and preparation process thereof
  • Rheumatic bone-setting transdermal patch and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of Active Part Components of APIs

[0026] Take 200g of the medicinal material Zijinlong, crush it into a coarse powder, soak it with 10% ethanol with a pH of 2.0 for 24 hours, filter the soaking liquid, continue to soak the dregs with 10% ethanol solution with a pH of 2.0 for 24 hours, filter, and take the filtrate , combined the two filtrates, concentrated the filtrate under reduced pressure at 60°C to a relative density of 1.05, no alcohol smell, cooled at room temperature, adjusted the pH of the concentrated medicinal solution to 8.0 with 10% sodium bicarbonate, extracted and alkalized with ethyl acetate The alkaloid reaction of the ethyl acetate extraction layer was negative, the ethyl acetate extract was combined, the ethyl acetate extract was extracted twice with distilled water, the water layer was discarded, the ethyl acetate layer was concentrated under reduced pressure, dried, and Zijin was obtained. Dragon extract 1.20g, set aside;

[0027] 200g...

Embodiment 2

[0030] Preparation of Active Part Components of APIs

[0031] Take 1500g of the medicinal material Zijinlong, crush it into a coarse powder, soak it with 50% ethanol with a pH of 3.0 for 48 hours, filter the soaking liquid, soak the dregs with 50% ethanol solution with a pH of 3.0 for 24 hours, filter, and take the filtrate , combined the two filtrates, concentrated the filtrate under reduced pressure at 60°C to a relative density of 1.10, no alcohol smell, cooled at room temperature, adjusted the pH of the concentrated medicinal solution to 9.0 with 5% sodium carbonate, and extracted the alkalized The medicinal solution, until the alkaloid reaction of the ethyl acetate extraction layer was negative, the ethyl acetate extract was combined, the ethyl acetate extract was extracted twice with distilled water, the water layer was discarded, the ethyl acetate layer was concentrated under reduced pressure, dried, and Zijinlong was obtained. Extract 12.5g, set aside;

[0032] Bitter...

Embodiment 3

[0035] Preparation of Active Part Components of APIs

[0036] Take 1000g of the medicinal material Zijinlong, crush it into a coarse powder, soak it with 30% ethanol with a pH of 4.0 for 48 hours, filter the soaking liquid, continue to soak the dregs with 30% ethanol solution with a pH of 4.0 for 24 hours, filter, and take the filtrate , combined the two filtrates, concentrated the filtrate under reduced pressure at 60°C to a relative density of 1.10, no alcohol smell, cooled at room temperature, adjusted the pH of the concentrated medicinal solution to 11.0 with 1% sodium hydroxide, extracted and alkalized with ethyl acetate The alkaloid reaction of the ethyl acetate extraction layer was negative, the ethyl acetate extract was combined, the ethyl acetate extract was extracted twice with distilled water, the water layer was discarded, the ethyl acetate layer was concentrated under reduced pressure, dried, and Zijin was obtained. Dragon extract 5.87g, set aside;

[0037]1000g ...

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Abstract

The invention relates to a rheumatic bone-setting transdermal patch which is formed by dactylicapnos root, cortex picrasmae, paniculate swallowwort root and rhizoma panacis M which are extracted, andeffective parts are refined, and then transdermal patch excipients are added to prepare the transdermal patch; the transdermal patch obtained by the invention has the characteristics of being convenient for carrying and using, high transdermal adsorption ratio, high effective ingredients and strong treating effect.

Description

technical field [0001] The present invention relates to a transdermal patch for rheumatism and traumatic injuries, in particular to a transdermal patch prepared by extracting and refining the active parts of raw materials Zijinlong, Bitterbark, Xu Changqing and Shui Notoginseng. It belongs to the field of pharmaceutical preparations. Background technique [0002] Fengshi Dieda Tincture is included in the orthopedics sub-volume of "National Compilation of Chinese Patent Medicine Standards". It has the effects of expelling wind and dampness, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. The traditional Chinese medicine preparation for joint and muscle pain is composed of Zijinlong, bitter bark, Xu Changqing and water Sanqi four herbs. In the prescription, Zijinlong relieves pain and stops bleeding; bitter bark clears away heat and dampness, detoxifies; Antipruritic; Water Panax notoginseng stops bleeding and dissipates blood stas...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/70A61K47/32A61P29/00
Inventor 关屹闫冬
Owner 北京化药科创医药科技发展有限公司
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