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Drug-delivery endovascular stent and method of use

A technology of internal stent and blood vessel, applied in the field of drug delivery vascular stent and its application

Active Publication Date: 2013-08-07
BIOSENSORS INT GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, stent and catheter cross-sections are physical limitations on coating thickness
The problem encountered with rough stents is that the thickness of the cross-section of the stent and catheter must be defined narrow enough to be able to pass through the blocked artery

Method used

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  • Drug-delivery endovascular stent and method of use
  • Drug-delivery endovascular stent and method of use
  • Drug-delivery endovascular stent and method of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Biolimus Drug release from stents in vitro

[0071] According to known methods, in 37 ℃ PBS pH 7.4 / Tween medium with Biolimus polymer coated II stent and has a Biolimus containing The abluminal microstructured stent for in vitro drug release. Perform periodic sampling and determine Biolimus by HPLC total amount. Figure 5 explained from Drug Release from II Scaffolds and Microstructured Scaffolds.

Embodiment 2

[0073] Animal Implantation Experiment

[0074] Will be with and without Biolimus The modified scaffolds were implanted into outbred piglets. Stents were placed using balloon catheters according to the standard porcine overstretch model with 10-20% overstretch. Piglets were predilated prior to stent placement.

[0075] After 28 days, the animal was euthanized according to an approved protocol, and the heart and surrounding tissues were removed from the animal.

[0076] A microscope with a digital camera was used to obtain high-resolution images of cross-sections of blood vessels that had been fixed into sections, and the results are shown in Figures 9A-9F middle. Perform histomorphometric analysis on this image as follows:

[0077] Stents and arteries were dissected and sectioned by a histologist. Samples were stained for various growth signals, cell proliferation, and other cellular debris. Histomorphometric measurements were performed as follows:

[0078] in mm 2...

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Abstract

A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.

Description

Background technique [0001] Complications, such as restenosis, are recurring problems in patients treated for atherosclerosis in the form of medical procedures such as percutaneous transluminal coronary angioplasty (PTCA). Restenosis is treated as a surgical procedure in which a medical device is surgically implanted in the diseased artery to prevent it from becoming clogged after surgery. [0002] Stents are generally cylindrical and are usually made of a biocompatible metal such as titanium or surgical steel. Most stents are collapsible and delivered to the blocked artery via a transluminal catheter. The stent is secured to the catheter and can expand by itself or by expansion of a balloon within the stent, which is removed when the device has been in place. An example of a general type of catheter is disclosed in Palmaz's US Patent Application Publication No. US 6,936,066 entitled "Complaint Implantable Medical Devices and Methods of Making Same." [0003] Restenosis and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/16A61F2/90
Inventor D·R·萨维奇J·E·舒尔茨R·E·贝茨S·法里阿比S·H·苏
Owner BIOSENSORS INT GROUP
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