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Drug-delivery endovascular stent and method of use

A technology for internal stents and blood vessels, applied in the field of drug delivery vascular stents

Inactive Publication Date: 2013-01-23
BIOSENSORS INT GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, stent and catheter cross-sections are physical limitations on coating thickness
The problem with rough stents is that the cross-sectional thickness of the stent and catheter must be defined narrow enough to pass through the blocked artery

Method used

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  • Drug-delivery endovascular stent and method of use
  • Drug-delivery endovascular stent and method of use
  • Drug-delivery endovascular stent and method of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Biolimus Drug release from stents in vitro

[0073] According to known methods, in 37 ℃ PBS pH 7.4 / Tween medium with Biolimus polymer coated II stent and has a Biolimus containing The abluminal microstructured stent for in vitro drug release. Perform periodic sampling and determine Biolimus by HPLC total amount. Figure 5 explained from Drug Release from II Scaffolds and Microstructured Scaffolds.

Embodiment 2

[0075] Animal Implantation Experiment

[0076] Will be with and without Biolimus The modified scaffolds were implanted into outbred piglets. Stents were placed using balloon catheters according to the standard porcine overstretch model with 10-20% overstretch. Piglets were predilated prior to stent placement.

[0077] After 28 days, the animal was euthanized according to an approved protocol, and the heart and surrounding tissues were removed from the animal.

[0078] A microscope with a digital camera was used to obtain high-resolution images of cross-sections of blood vessels that had been fixed into sections, and the results are shown in Figures 9A-9F middle. Perform histomorphometric analysis on this image as follows:

[0079] Stents and arteries were dissected and sectioned by a histologist. Samples were stained for various growth signals, cell proliferation, and other cellular debris. Histomorphometric measurements were performed as follows:

[0080] in mm 2...

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Abstract

The invention relates to a drug-delivery endovascular stent and a method of use. More specifically, the invention relates to a radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.

Description

[0001] This application is a divisional application, the application number of the original application is 200780046647.6, the application date is October 19, 2007, and the title of the invention is "drug delivery intravascular stent and its use method". technical field [0002] The invention relates to a drug-delivering intravascular stent and a method for using the same. Background technique [0003] Complications, such as restenosis, are recurring problems in patients treated for atherosclerosis in the form of medical procedures such as percutaneous transluminal coronary angioplasty (PTCA). Restenosis is treated with stenting, in which a medical device is surgically implanted in a diseased artery to prevent it from becoming clogged after surgery. [0004] Stents are generally cylindrical and are usually made of a biocompatible metal such as titanium or surgical steel. Most stents are collapsible and delivered to the blocked artery via a transluminal catheter. The stent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/91A61F2/915A61M31/00A61L31/02A61L31/16
CPCA61L31/022A61F2/91A61F2/0077A61L2300/416A61F2002/91541A61L2300/60A61L31/16A61F2/915A61F2250/0067A61L27/54A61F2/07A61F2/82
Inventor D·R·萨维奇J·E·舒尔茨R·E·贝茨S·法里阿比S·H·苏
Owner BIOSENSORS INT GROUP
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