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Buffer-contained Chinese traditional medicine panax notoginseng saponins

A technology of Panax notoginseng saponins and traditional Chinese medicine preparations, which can be applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, drug combinations, etc., and can solve problems such as reduced solubility and impact on product quality

Inactive Publication Date: 2010-03-17
YUNNAN YUNKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PNS in aqueous solution, if the pH value is not selected properly, it is easy to make it hydrolyzed, the solubility is reduced, opalescence, white spots, white blocks and even flocculent precipitation will occur in the liquid medicine, which will affect the quality of the product

Method used

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  • Buffer-contained Chinese traditional medicine panax notoginseng saponins
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  • Buffer-contained Chinese traditional medicine panax notoginseng saponins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: PNS injection

[0061] Take 50g of PNS, add 8.0g of sodium chloride, 1.56g of disodium hydrogen phosphate, 0.20g of sodium dihydrogen phosphate, add activated carbon (5-10% of PNS), add appropriate amount of water for injection, boil, let cool, stand still, and filter , add water for injection to 1000ml, potting, and sterilizing, to obtain.

Embodiment 2

[0062] Embodiment 2: PNS injection

[0063] Take 10g of PNS, 5g of citric acid, 4.0g of sodium citrate, adjust the pH value to 7.4, add activated carbon (5-10% of PNS), add an appropriate amount of water for injection, boil, let cool, stand still, filter, and add injection Make it up to 1000ml with water, potting, and sterilizing.

Embodiment 3

[0064] Embodiment 3: PNS injection

[0065] Take 100g of PNS, 2.2g of acetic acid, 8g of sodium acetate, adjust the pH value to 7.4, add activated carbon (5-10% of PNS), add an appropriate amount of water for injection, boil, let cool, stand still, filter, add water for injection to 1000ml, Potting, sterilization, that is.

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Abstract

The invention provides a buffer-contained Chinese traditional medicine panax notoginseng saponin which is characterized in that the panax notoginseng saponins (PNS) is taken as active component and added with the buffer, thus preparing the Chinese traditional medicine. The concentration of the panax notoginseng saponin is 10-200g / L; the pH value of the panax notoginseng saponins is 6-9; the bufferis 2.2 g / L of acetic acid and 8g / L of sodium acetate, or 5g / L of citrate and 40g / L of sodium citrate, or 1g / L of lactic acid, or 6.5g / L of tartaric acid and 12g / L of sodium tartrate, or 1.56-17g / L ofdisodium hydrogen phosphate and 0.2-7.1g / L of sodium dihydrogen phosphate, or 0.05g / L of sodium bicarbonate and 0.6g / L of sodium carbonate. The buffer is added in the PNS injection solution, the pH value is adjusted to 7.4, the hydrolysis of PNS can be reduced, and the stability of the PNS injection solution is increased.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a Chinese medicinal preparation of Panax notoginseng saponins containing a buffer. Background technique [0002] Panax notoginseng [Pana~notogin~eng(Burk.) F.H.Chen], also known as Tianqi, Panax notoginseng, Panax notoginseng, Sanqi, etc., is a plant of the genus Panax of Araliaceae, mainly produced in Yunnan, Guangxi and other places. Wild or cultivated; sweet, slightly bitter, warm in nature; enters liver, stomach, and large intestine meridians. It has the function of "stopping bleeding, removing blood stasis, reducing swelling and relieving pain". It can be used to treat traumatic bleeding, hemoptysis, epistaxis, vaginal bleeding, bloody dysentery and other bleeding disorders. [0003] The main component of Panax notoginseng is total saponins of Panax notognseng (PNS). Since the 1940s, scholars at home and abroad have conducted a series of st...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K47/12A61K47/02A61P7/02A61P9/10
Inventor 陈彤甘献文肖娜吴廷丽张要武赵嵩月
Owner YUNNAN YUNKE PHARMA
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