Externally applied patch for treating phlebitis and method for producing the same

A production method and technology for phlebitis, applied in the field of external patches for treating phlebitis, can solve problems such as difficult venipuncture, drug absorption disorders, local redness, swelling, hard pain, etc., achieve short inclusion time, easy control of process conditions, and high product quality High yield effect

Inactive Publication Date: 2010-03-31
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Some phlebitis is a non-infectious inflammation caused by infusion, which makes drug absorption disorder, local redness, swelling and hard pain, and it is difficult to continue medication, especially for children's venipuncture.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 (high dose)

[0015] The external patch for treating phlebitis and the preparation method are as follows: 10 kg of safflower, 10 kg of rhubarb, and 10 kg of mirabilite.

[0016] Taking safflower, rhubarb and mirabilite in proportion, crushing and grinding them respectively, and homogenizing through a micron homogenizer and a nanometer homogenizer, the particle size of each component is 100-200 μm.

[0017] After the quality inspection of the particle size, the ground raw materials were put into the colloid mill for CO 2 Supercritical extraction, adding β-cyclodextrin and appropriate amount of water, the weight ratio of raw material drug to β-cyclodextrin is 1:6. Grind the colloid mill evenly, keep the speed at 3000r / min, adjust the distance between the mills to 5 μm, continuously and slowly add an appropriate amount of ethanol-dissolved ingredients of the raw material drug, soak for 6 hours, refrigerate at 4°C for 24 hours, and vacuumize. Vacuum-dry at 40...

Embodiment 2

[0021] Embodiment 2 (low dosage)

[0022] The external patch for treating phlebitis and the preparation method are as follows: 5 kg of safflower, 3 kg of rhubarb, and 3 kg of mirabilite.

[0023] Taking safflower, rhubarb and mirabilite in proportion, crushing and grinding them respectively, and homogenizing through a micron homogenizer and a nanometer homogenizer, the particle size of each component is 100-200 μm.

[0024] After the quality inspection of the particle size, the ground raw materials were put into the colloid mill for CO 2 Supercritical extraction, adding β-cyclodextrin and appropriate amount of water, the weight ratio of raw material drug to β-cyclodextrin is 1:6. Grind the colloid mill evenly, keep the speed at 3000r / min, adjust the distance between the mills to 5 μm, continuously and slowly add an appropriate amount of ethanol-dissolved ingredients of the raw material drug, soak for 6 hours, refrigerate at 4°C for 24 hours, and vacuumize. Vacuum-dry at 40°C...

Embodiment 3

[0028] Embodiment 3 (medium dose)

[0029] The external patch for treating phlebitis and the preparation method are as follows: 7.5 kg of safflower, 6.5 kg of rhubarb, and 6.5 kg of mirabilite.

[0030] Taking safflower, rhubarb and mirabilite in proportion, crushing and grinding them respectively, and homogenizing through a micron homogenizer and a nanometer homogenizer, the particle size of each component is 100-200 μm.

[0031] After the quality inspection of the particle size, the ground raw materials were put into the colloid mill for CO 2 Supercritical extraction, adding β-cyclodextrin and appropriate amount of water, the weight ratio of raw material drug to β-cyclodextrin is 1:6. Grind the colloid mill evenly, keep the speed at 3000r / min, adjust the distance between the mills to 5 μm, continuously and slowly add an appropriate amount of ethanol-dissolved ingredients of the raw material drug, soak for 6 hours, refrigerate at 4°C for 24 hours, and vacuumize. Vacuum-dry ...

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PUM

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Abstract

The invention provides an externally applied patch for treating phlebitis and a method for producing the same. The invention contains the following components in proportion by weight: safflower 5-10,rheum officinale 3-10, saltcake 3-10; the invention includes the steps of: proportionally mixing raw materials, grinding until particle diameter of each component is 100-200 mu m; using CO2 supercritical extraction, fractionating acquired distillates with a fractionating tower, mixing each component in the formula into nano medicinal pulp according to the formula proportionality through the nano dispersing apparatus, adding accelerating agent for percutaneous absorption and contact adhesive into the circular type low temperation drying coater, and after coating, executing shearing, quality test, packaging and then sending the product into warehouse. The invention uses a scientific method for processing and extracting medicinal materials, which are filled in the framework of the substrate,and the paster substrate has a good compatibility with skin, and is good for medicament molecule to pass; the medicament has the advantages of slow release, smooth and steady administration, small irritation without toxic and side effects, thereby resolving the problem that oral medication and injection have toxic and side effects for human body and preventing toxic and side effects of medicamenttaken orally.

Description

technical field [0001] The invention relates to a traditional Chinese medicine patch, in particular to an external patch for treating phlebitis and a preparation method thereof. Background technique [0002] Some phlebitis is a non-infectious inflammation caused by infusion, which can cause drug absorption disorders, local redness, swelling, hard pain, and difficulty in continuing medication, especially in children with venipuncture. Doctor trained in Western medicine treats with 2% procaine local closure. Contents of the invention [0003] The main purpose of the present invention is to solve the toxic and side effects of oral medicines and injections on the human body, and provide an external patch for treating phlebitis that avoids the toxic and side effects of oral administration and does not undergo the first-pass effect of the liver and its production method. [0004] The technical solution adopted by the present invention to solve its technical problems is: [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/70A61K47/40A61K47/02A61P9/00A61K33/04
Inventor 梁秉文周英超李扬
Owner TIANJIN ZHONGBAO PHARMACY
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