Lanthanum fullerenol and application in preparing medicaments for inhibiting tumor growth

The technology of a tumor drug, fullerol, is applied in the direction of anti-tumor drugs, drug combinations, heavy metal active ingredients, etc., which can solve the problems of research and application limitations, inability to function, etc., and achieve high tumor inhibition rate, low toxicity, and small dosage. Effect

Active Publication Date: 2010-04-21
INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because fullerenes and many of their derivatives are hydrophobic and cannot interact with "target mo

Method used

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  • Lanthanum fullerenol and application in preparing medicaments for inhibiting tumor growth
  • Lanthanum fullerenol and application in preparing medicaments for inhibiting tumor growth
  • Lanthanum fullerenol and application in preparing medicaments for inhibiting tumor growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Gd@C 2m (OH) x preparation of

[0053] First step Gd@C 2m Synthesis

[0054] High-purity (>99.999%) Gd 2 o 3 Mix it with high-purity graphite powder (>99.999%) according to the atomic ratio Gd:C=0.5~3:100, and press it into a mold to make a graphite-metal hybrid electrode; or drill a graphite rod with a diameter of 6~20mm and fill it with oxide Gadolinium yields graphite-metal hybrid electrodes. After high-temperature sintering at 1000-2000°C, use the inert gas arc discharge method to synthesize metallofullerene Gd@C 2m . The inert gas is He or Ar, the pressure is 50-600 Torr, and the current is 80-500A.

[0055] The second step Gd@C 82 and Gd@C 60 separation and purification of

[0056] a. Using high temperature reflux plus high temperature and high pressure two-step high-efficiency extraction method to extract and separate carbon nano-like substances. Firstly, the arc-shaped discharge soot is refluxed in toluene at 100-200°C for 12-24 hours, and then extra...

Embodiment 2

[0067] Determination of Gd@C 82 (OH) 22 and Gd@C 82 (OH) 12 hydroxyl number

[0068] Gd@C 82 (OH) 22 (a) and Gd@C 82 (OH) 12 (b) The XPS spectrum of the C1s electron is as follows image 3 As shown, the relative strength between C-C and C-O bonds was used to analyze the Gd@C 82 (OH) x The number of hydroxyl groups in . figure 2 The Gaussian fitting analysis of the solid line in the middle shows that there are two different carbon atoms in the molecule: the peak position at 284.4eV is the binding energy of the sp2 hybridized carbon atom (C-C) that is not connected to other groups; the peak position at 285.3eV The peaks are hydroxylated carbon atoms (C-OH).

Embodiment 3

[0070] La@C 2m (OH) x preparation of

[0071] Using Gd@C prepared as above 82 A similar method was used to prepare La@C 82 and La@C 60 .

[0072] (1) Metal fullerenol La@C 82 (OH) 18 Synthesis

[0073] Using the NaOH method, the La@C 82 React with 28% NaOH solution, and after a series of separation and purification processes, after removing NaOH, La@C with a purity greater than 99.99% is obtained 82 (OH) 18 The product was stored freeze-dried.

[0074] (2) Metal fullerenol La@C 60 (OH) 22 Synthesis

[0075] Using the NaOH method, the La@C 60 React with 35% NaOH solution, and then go through a series of separation and purification processes to remove NaOH to obtain La@C with a purity greater than 99.99%. 60 (OH) 22 The product was stored freeze-dried.

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Abstract

The invention relates to lanthanum fullerenol and application in preparing medicaments for inhibiting tumor growth, in particular to lanthanum fullerenol nanoparticles with the general formula of M@C2m(OH)x and the application thereof in preparing medicaments for inhibiting tumor growth, wherein M is La rare earth metal, m is equal to 41 or 30, and X is equal to or larger than 10 and is less than 50; and because of the reorganization of adjacent hydroxyl groups, the quantity of O on C82 carbon cage is actually different from the quantity of H, and therefore, the general formula can be written in the form of M@C2mOXHY. Compared with cyclophosphamide, cis-platinum, taxol, and the like which are clinically and widely used, the lanthanum fullerenol M@C2m(OH)x or M@C2mOXHY has the advantages of low consumption and toxicity and high rate of tumor inhibition.

Description

[0001] This application is a divisional application, the application number of the original application is 200610152170.7, the application date is September 15, 2006, and the title of the invention is "Metal Fullererol and Its Application in the Preparation of Drugs for Inhibiting Tumor Growth". technical field [0002] The invention relates to a novel nanometer material and its application in biomedicine. Specifically, it involves the general formula M@C 2m (OH)x metal fullerenol nanoparticles and its application in the preparation of drugs for inhibiting tumor growth, wherein M is selected from rare earth metals such as Gd and La, and 10≤X<50. Background technique [0003] Malignant tumor is an important disease that threatens human health and has become the main cause of human death. In China, liver cancer, lung cancer, gastric cancer and breast cancer are the tumors with the highest incidence rates. At present, at least 7 million people die of cancer every year in t...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P35/00A61P35/02A61K33/24
Inventor 赵宇亮陈春英邢更妹
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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