Solution of chitosan, preparation method thereof and using method thereof

A chitosan solution, chitosan technology, applied in the field of its preparation, chitosan solution, promotion of gene transduction efficiency mediated by adenovirus vector
CN101698712BActive Publication Date: 2013-10-16INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
Publication Date
2013-10-16

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Abstract

The invention relates to the fields of macromolecular substances, physical chemistry, molecular biology and virology, in particular to solution of chitosan, preparation method thereof and a method for using the same to improve the efficiency of gene transduction mediated by an adenoviral vector.
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Description

technical field

[0001] The invention relates to the fields of macromolecular substances, physical chemistry, molecular biology and virology. Specifically, the present invention relates to a chitosan solution, a preparation method thereof and a method for using it to promote gene transduction efficiency mediated by an adenovirus vector. Background technique

[0002] Chitosan is the product of deacetylation of chitin, and the degree of deacetylation can be 65% to 100%. Chitosan is the only known cationic polysaccharide, insoluble in water and organic solvents, soluble in dilute acids with pH<6.5, including adipic acid, hydrochloric acid, acetic acid, formic acid, lactic acid, malic acid, propionic acid and succinic acid Acid etc. Chitosan has the characteristics of non-toxicity, good biocompatibility and biodegradability, so it is widely used in the fields of food, medicine and biology.

[0003] Although chitosan has the advantages of non-toxicity, good biocompatibility ...

Claims

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