Methods, compounds, and compositions for treating metabolic disorders and diabetes
A diabetes, compound technology, applied in the field of prevention or treatment of complications of kidney disease, can solve problems such as limited regenerative capacity
Inactive Publication Date: 2010-06-09
BELLUS HEALTH (INT) LTD (CH)
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, their ability to regenerate is limited
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0192] An example of a 400 mg capsule formulation of 1,3 propane disulfonic acid disodium salt is described below.
[0193] 400 mg capsules of 1,3 propane disulfonic acid disodium salt were prepared by filling #0 white opaque hard gelatin capsules with white powder containing 400 mg 1,3 propane disulfonic acid disodium salt and 40 mg excipients.
[0194] original material
[0195] Lactose monohydrate (316Fast-Flo)
[0196] * MHS - Manufacturer's Internal Standard
Embodiment 2
[0198] A pharmaceutical composition was formulated as described in Example 1 using 1,3 propane disulfonic acid as active substance.
Embodiment 3
[0200] A pharmaceutical composition was formulated as described in Example 1 using 1,2-ethanedisulfonic acid as active substance.
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Disclosed herein are methods, compounds and compositions for preventing or treating a pancreatic disorder, including diabetes mellitus (e.g. type 1 and / or type 2 diabetes). The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for improving or at least stabilizing pancreatic function(s) and for the prevention and / or treatment of metabolic syndrome and its components. The invention further relates to methods, compounds and compositions for the prevention and / or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in patients in need thereof, including diabetic patients.
Description
[0001] related application [0002] This application claims priority under 35 USC 119(e) to U.S. Provisional Application 60 / 916,488 filed May 7, 2007 and to PCT / IB2006 / 004262 filed December 22, 2006 under 35 USC 365(a) priority, both of which are incorporated herein by reference. This application is also related to US Patent Application Serial No. 11 / 643,946, filed December 22, 2006, which is incorporated herein by reference. field of invention [0003] The invention also relates to methods, compounds and compositions for preventing or treating complications of renal disease. The present invention further relates to methods, compounds and compositions for the prevention and / or treatment of dyslipidemia, common complications of kidney disease, chronic kidney disease and nephropathy. The compounds, methods and compositions of the present invention are also useful in the prevention or treatment of pancreatic disease, diabetes mellitus, insulin resistance, metabolic disease (in...
Claims
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IPC IPC(8): A61K31/10A61P3/08A61P3/10
CPCY02T10/121A61K31/10A61P1/18A61P3/00A61P3/10A61P3/08
Inventor 温迪·霍克帕维尔·哈姆特
Owner BELLUS HEALTH (INT) LTD (CH)