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Method for enriching and purifying cardiac glycoside of wormseed mustard herb

A technology of cinnamon sugar mustard and cardiac glycosides, which is applied in the field of purification of cardiac glycosides and cardiac glycosides in cassia bamboo sugar mustard by using macroporous adsorption resin to enrich and purify, can solve the problems of low extraction purity and low extraction rate, and achieves High extraction purity, large adsorption capacity, fast adsorption and fast analysis

Inactive Publication Date: 2010-06-16
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and to provide a method for enriching and purifying cardiac glycosides in candied mustard by using macroporous adsorption resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a kind of method utilizing macroporous adsorption resin to enrich and purify cardiac glycosides in sugar mustard osmanthus, the steps are as follows:

[0027] (1) Sieve through a 60-mesh sieve after crushing the dried osmanthus bamboo candied mustard, and soak and extract with ethyl acetate 10 times the volume of the osmanthus bamboo candied mustard powder for 48 hours;

[0028] (2) suction-filtering the osmanthus osmanthus extract treated in step (1) to obtain the extract and reclaim the initial extract of the solvent under reduced pressure;

[0029] (3) Heating and dissolving the obtained initial extract with water, adding acetic acid ethanol with a volume 20 times the volume of the extract aqueous solution for extraction, then adjusting its pH value to 9.0 with alkali, standing, suction filtration, and recovering the solvent under reduced pressure to obtain a strong Heart glycoside crude extract;

[0030] (4) the obtained cardiac glycoside extract is a...

Embodiment example 2

[0035] Implementation case 2: a method for enriching and purifying cardiac glycosides in sugar mustard with macroporous adsorption resin, the steps are as follows:

[0036] (1) Pass through a 10-mesh sieve after crushing the dried osmanthus bamboo candied mustard, soak and extract with acetone 20 times the volume of osmanthus bamboo candied mustard powder for 12 hours, then reflux and extract for 4 hours;

[0037] (2) suction-filtering the osmanthus osmanthus extract treated in step (1) to obtain the extract and reclaim the initial extract of the solvent under reduced pressure;

[0038] (3) Heat and dissolve the obtained initial extract with water, add acetic acid ethanol whose volume is 10 times the volume of the extract aqueous solution for extraction, then use ammonia water to adjust its pH value to 7.0, leave it to stand, suction filter, and concentrate under reduced pressure to strengthen the heart Glycoside crude extract;

[0039] (4) the obtained cardiac glycoside crud...

Embodiment example 3

[0044] Implementation case 3: a method for enriching and purifying cardiac glycosides in sugar mustard by using macroporous adsorption resin, the steps are as follows:

[0045] (1) After crushing the dried osmanthus bamboo candied mustard, pass through an 80-mesh sieve, and extract with 75% ethanol with 15 times the volume of osmanthus bamboo candied mustard powder for 6 hours;

[0046] (2) suction-filtering the osmanthus osmanthus extract treated in step (1) to obtain the extract and reclaim the initial extract of the solvent under reduced pressure;

[0047] (3) Heating and dissolving the obtained initial extract with water, adding acetic acid ethanol whose volume is 10 times the volume of the extract aqueous solution for extraction, then adjusting its pH value to 11.0 with aqueous sodium hydroxide solution, standing, suction filtration, and concentrating under reduced pressure Obtain the crude extract of cardiac glycosides;

[0048] (4) the obtained pentacardiac glycoside c...

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Abstract

The invention belongs to the field of natural organic chemistry and relates to a method for enriching and purifying cardiac glycoside of wormseed mustard herb by macroporous absorption resin. The method is characterized in that: the method adopts macroporous absorption technology to separate and purify the cardiac glycoside, has good adsorptive selectivity on the cardiac glycoside, rapid adsorption and desorption, high adsorption capacity, convenient and rapid extraction, rich source of raw materials, low production cost, obvious separation effect and high extraction purity, can obtain a cardiac glycoside semifinished product with content of over 35 percent and a cardiac glycoside final product with content of over 98 percent, and overcomes the disadvantages of low extraction rate and extraction purity in the prior art. The macroporous absorption resin with stable physicochemical property, large surface area, high exchange speed, high mechanical strength, strong antipollution capacityand good thermal stability is selected, can selectively adsorb the cardiac glycoside from solution through physical adsorption, and has rapid adsorption and desorption and large adsorption capacity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a method for purifying cardiac glycosides, in particular to a method for enriching and purifying cardiac glycosides in candied mustard by using macroporous adsorption resin. Background technique: [0002] Osmanthus bamboo candied mustard: [synonym] Dashui Shuihua, Calendula ("Inner Mongolia Chinese Herbal Medicine"), Xiheri-Heqi (Mongolian name). Annual or biennial herb, 30-150 cm high, with two or three-pronged hairs throughout the plant. The stem is erect, with branches in the upper part. Single leaves alternate; linear or lanceolate, apex slightly pointed, margin wavy or shallow and long notched, base attenuate; nearly sessile. The racemes are axillary at the top; the flowers are small; the petals are 4, yellow, spatulate, arranged in a cross shape; the stamens are 6, 4 long and 2 short. Silique cylindrical, about 1-2 cm long, ribbed, cracked when mature, short stalk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P9/06A61P7/10A61P1/14
Inventor 姚德坤姚德利闫峰姚航
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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