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Method for extracting magnolol and honokiol from magnolia officinalis

A technology of honokiol and magnolol, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the difficulty of separating magnolol and honokiol, the large amount of organic solvent used, and the extraction time Long and other problems, to achieve the effect of shortening the production cycle, less corrosive equipment, and short extraction time

Active Publication Date: 2013-01-23
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention first utilizes mechanochemical reaction technology to extract magnolol, and then extracts honokiol by strong alkali, which solves the problems of low extraction rate, difficulty in separating magnolol and honokiol, and extraction time in the production process. Long, high temperature, large amount of organic solvents, etc., and improve product quality, reduce production costs, and reduce pollution from the source

Method used

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  • Method for extracting magnolol and honokiol from magnolia officinalis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take Magnolia officinalis powder 10g, add sodium carbonate and borax (mass ratio 2:1) altogether 0.1g, grind to powder particle size D 90 25 μm (detected by a particle size analyzer, the same below), add 50ml of water, stir at 5°C for 20 minutes, centrifuge to obtain precipitate A and supernatant A, add 6mol / L hydrochloric acid to the supernatant A to adjust the pH value to 1.0, static Place and centrifuge, get the precipitate to be the magnolol extract, the yield of magnolol is 0.40%, and the content of magnolol is 46.3%; take the precipitate A, add 2.0g sodium hydroxide, 250ml water, at 5 ℃ Stir for 60 minutes, centrifuge, take the supernatant and add 6mol / L hydrochloric acid to adjust the pH value to 2.0, centrifuge after standing, take the precipitate and get the honokiol extract, the yield of honokiol is 0.44%, and the honokiol The phenol content was 49.5%.

Embodiment 2

[0037] Take Magnolia officinalis powder 10g, add potassium carbonate 0.5g, grind to powder particle size D 90 95μm, add 100ml of water, stir at 20°C for 10min, centrifuge to obtain precipitate A and supernatant A, add glacial acetic acid to adjust the pH value of supernatant A to 5.0, let it stand and centrifuge, and take the precipitate as magnolol Extract, the yield is 1.20%, the content is 60.1%; take the precipitate A, add 1.0g calcium hydroxide, 150ml water, stir at 40°C for 15min, centrifuge, take the supernatant, add 6mol / L hydrochloric acid to adjust the pH value to 3.0, leave it to stand and then centrifuge to get the precipitate to be the honokiol extract, with a yield of 0.53% and a content of 62.1%.

Embodiment 3

[0039] Take 10g of magnolia powder, add 1.0g of borax, mix and grind to powder particle size D 90 57μm, add 100ml of water, stir at 40°C for 20min, centrifuge to obtain precipitate A and supernatant A, add 6mol / L hydrochloric acid to the supernatant A to adjust the pH value to 2.0, let stand and then centrifuge, take the precipitate and get the thickness Parkol extract, the yield is 1.30%, the content is 25.3%; take the precipitate A, add 0.5g calcium oxide, 100ml water, stir at 20°C for 30min, centrifuge, take the supernatant, add 6mol / L hydrochloric acid to adjust the pH When the value reaches 5.0, it is centrifuged after standing, and the precipitate is Honokiol extract, the yield is 0.57%, and the content is 63.2%.

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Abstract

The invention discloses a method for extracting magnolol and honokiol from magnolia officinalis; the method includes that: magnolia officinalis powder and solid phase weak base reagent are mixed according to the weight ratio of 1:0.01-1, the mixture is grinded to obtain powder with granularity analysis result D90 of 10-200 um, and then water is added to the powder, the mixture is stirred sufficiently and is centrifuged to obtain sediment A and supernate A, acid X with pH value of 1.0-6.0 is added to the supernate A, then the supernate is centrifuged after standing to obtain sediment B as magnolol extractive. The invention firstly adopts mechanical chemical reaction technique to extract magnolol, and then adopts alkaline process to extract honokiol, has the advantages of high extraction rate, good separation effect of magnolol and honokiol, and short production cycle, and is the extraction and separation process with good popularization and application prospect.

Description

(1) Technical field [0001] The invention relates to a method for extracting magnolol and honokiol from magnolia bark. (2) Background technology [0002] Magnolia officinalis warm in nature, bitter in the mouth, pungent, enters spleen, stomach, lung. It has good anti-tumor, anti-virus, anti-caries, analgesic, anti-inflammatory and other pharmacological activities. At present, it is widely used in food, medicine, daily chemical, health care products and many other aspects. The main components in magnolia bark are phenolic substances, including magnolol (magnolo1) (formula II), honokiol (honokio1) (formula I), isomagnolol (iso-magnolo1), 8,9-di Hydroxydihydrohonokiol, 8,9-dihydroxy-7-methoxydihydrohonokiol, 8,9-dihydroxydihydrohonokiol, and the like. Among them, magnolol and honokiol account for more than 95% of the total magnolol, and are the main medicinal components. The structural formulas of magnolol and honokiol are as follows: [0003] [0004] At present, there ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/21C07C37/68
Inventor 谢捷苏为科朱兴一王平李红娟
Owner ZHEJIANG UNIV OF TECH
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