Method and device for establishing superficial sensory disturbance animal model

Abstract

The invention provides a method and a device for establishing a superficial sensory disturbance animal model. The method comprises the following steps: (1) establishing operant conditioned reflex avoiding noxious stimulation for animals; (2) preparing hemiplegia models for animals which establish conditioned reflex; and (3) only exposing the affected limbs of hemiplegia animals, and screening superficial sensory disturbance. The device is suitable for the method for establishing the operant conditioned reflex avoiding shock stimulation for animals, which comprises a box body, a circuit control device, and a shock device and a power-off device which are positioned at the bottom of a box. The method for establishing the superficial sensory disturbance animal model provided by the invention can accurately record the performance of animals in the process of experiments in detail and facilitate the collation and statistics of data, can establish a superficial sensory disturbance model of affected limbs of the animals after stroke, has the advantages of simple operation, accurate data, easy training for animals, short test cycle and the like; and the corresponding device has simple structure and easy operation.

Description

technical field

[0001] The invention relates to the field of detection and identification technology methods, and relates to a method and a device for establishing an animal model of shallow sensory impairment based on animal operant conditioning. Background technique

[0002] In 1903, the Russian physiologist I.P. Pavlov discovered the phenomenon of conditioned reflex through animal experiments and proposed the theory of conditioned reflex. His main interest was the study of digestive activity in dogs, initially by observing dogs salivating profusely when they craved food. He thinks it's unlikely that dogs salivating before they're actually given food is an innate response. There is good reason to think that by this time the animal has learned to associate a certain signal or the smell of the food with the food itself, and that salivation is due to this learning. So in craving food, the dog salivates in response to a new stimulus that heralds the imminent arrival of food,...

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