Medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof

A technology of anti-tumor activity and immune regulation, applied in the direction of anti-tumor drugs, drug combinations, applications, etc., can solve the toxic side effects and drug resistance of radical surgery chemical drug treatment, the limitation of the effect of tumor treatment, the limitation of the means of treatment of tumor, etc. problem, to achieve the effect of increasing the number of white blood cells and red blood cells in the peripheral blood of mice, increasing immunity, and low cost

Inactive Publication Date: 2010-07-21
SHANGHAI UNIV
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Problems solved by technology

[0003] The diagnosis and treatment of tumors are currently mainly focused on surgical treatment, radiotherapy and chemical drug treatment. These means of treating tumors are partially limited. Therefore, the use of single or compound Chinese herbal medicines and the combination of Chinese and Western methods to treat tumors have attracted increasing attention.
[0004] In the treatment of tumor diseases with traditional Chinese medicine, on the one hand, because a large number of researches are mainly focused on single Chinese medicines, and single Chinese medicines have certain biases and limitations in their physical and chemical properties and treatment approaches, so it is inevitable to use Its therapeutic effect on tumors is limited, so if two or more traditional Chinese medicines are used together to learn from each other's strengths, a certain synergistic effect may be produced to make the therapeutic effect of tumors better; The market price is expensive, so patients will undoubtedly have a certain economic burden during use, so if there is a Chinese medicine composition that has both good pharmacological health care effects and low economic costs, it will not only reduce the burden on patients. It is also a new opportunity for the field of medical and healthcare products

Method used

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  • Medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof
  • Medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof
  • Medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the influence of traditional Chinese medicine composition on tumor

[0024] Take S180 ascites tumor mice about 7-8 days old, pull the cervical spine to kill, place in 75% ethanol solution, take out the tumor fluid under aseptic conditions, and dilute it to 2×10 with sterile normal saline. 7 Afterwards, inoculate subcutaneously in the armpit of the right forelimb of the mouse, 0.1 mL / mouse, to establish the S180 tumor-bearing mouse model. The S180 mouse model was then divided into five groups: model group, traditional Chinese medicine composition group (Ganoderma lucidum: Astragalus ∈ [0.5, 3]), Ganoderma lucidum single group, Astragalus root alone group, and cyclophosphamide group, with 8 mice in each group. Each group of traditional Chinese medicine was intragastrically administered the corresponding traditional Chinese medicine at a dose of 500mg / kg; the model group was intragastrically administered with the same amount of normal saline; / kg. Each grou...

Embodiment 2

[0028] Embodiment 2: The influence of traditional Chinese medicine composition on immune cells

[0029] Take S180 ascites tumor mice about 7-8 days old, pull the cervical spine to kill, place in 75% ethanol solution, take out the tumor fluid under aseptic conditions, and dilute it to 2×10 with sterile normal saline. 7 Afterwards, inoculate subcutaneously in the armpit of the right forelimb of the mouse, 0.1 mL / mouse, to establish the S180 tumor-bearing mouse model. The S180 mouse model was then divided into six groups: normal group, model group, Chinese medicine composition group (Ganoderma lucidum: Astragalus ∈ [0.5, 3]), Ganoderma lucidum single group, Astragalus root alone group, cyclophosphamide group, 8 Only. Each group of traditional Chinese medicine was intragastrically administered the corresponding traditional Chinese medicine at a dose of 500mg / kg; the model group was intragastrically administered with the same amount of normal saline; / kg; normal group without any...

Embodiment 3

[0033]Embodiment three: the impact of Chinese medicine composition on immune organs

[0034] Take S180 ascites tumor mice about 7-8 days old, pull the cervical spine to kill, place in 75% ethanol solution, take out the tumor fluid under aseptic conditions, and dilute it to 2×10 with sterile normal saline. 7 Afterwards, inoculate subcutaneously in the armpit of the right forelimb of the mouse, 0.1 mL / mouse, to establish the S180 tumor-bearing mouse model. The S180 mouse model was then divided into six groups: normal group, model group, Chinese medicine composition group (Ganoderma lucidum: Astragalus ∈ [0.5, 3]), Ganoderma lucidum single group, Astragalus root alone group, cyclophosphamide group, 8 Only. Each group of traditional Chinese medicine was intragastrically administered the corresponding traditional Chinese medicine at a dose of 500mg / kg; the model group was intragastrically administered with the same amount of normal saline; / kg; normal group without any treatment....

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Abstract

The invention relates to a medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof. The composition comprises ganoderma lucidum extract and radix astragali extract in mass ratio of 1:0.5-3, wherein the ganoderma lucidum extract comprises the following effective medicinal ingredients in percentage by weight: 50-70% of ganoderma lucidum polysaccharides and 6-10% of ganoderma lucidum total triterpene; and the radix astragali extract comprises the effective medicinal ingredient in percentage by weight: 20-45% of radix astragali polysaccharide. Based on traditional Chinese medicine pharmacological animal experiments, the composition of the invention is found having anti-tumor effect, improves the immunocompetence of a body, and has a medicine and food dual-purpose property. In addition, compared with single ganoderma lucidum, the use of the radix astragali as raw material reduces the cost of the traditional Chinese medicine composition, the anti-tumor and immunoregulation curative effects are close to the curative effects of the same amount of the single ganoderma lucidum, and the invention has certain economic value.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition with antitumor activity and immune regulation function and its application. Background technique [0002] Currently, cancer is the disease with the highest mortality rate in my country. According to the survey, the number of cancer patients in the world has reached 10 million each year, and the death toll is close to 7 million. The number of cancer patients in my country accounts for a quarter of the global incidence, about 2.5 million, and every year The number of people who died of tumor diseases has reached about 1.5 million, and the number is still on the rise. Facing such a severe situation of tumor morbidity and death, how to prevent and treat tumors through effective measures has become the primary task of human disease prevention and treatment, and it is also a major issue that the whole society needs to solve urgently. [0003] The diagnosis and treatment of tumors are curren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P35/00A61P37/02A23L1/29A23L33/00
Inventor 翁新楚张佳俊侯建平廖鲜艳王沂
Owner SHANGHAI UNIV
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