Elemene sustained-release tablets
一种榄香烯、缓释片的技术,应用在抗癌药榄香烯缓释片及其制备领域,能够解决未发现等问题,达到易于控制、降低血药浓度波动、血药浓度维持时间长的效果
Active Publication Date: 2010-08-25
谢恬
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No patent documents have been found about the use of elemene in the treatment of esophageal cancer, lung cancer, brain tumor, liver cancer, cervical cancer, cancerous chest, ascites and other diseases by means of sustained-release tablets
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Abstract
The invention discloses elemene sustained-release tablets, which are prepared from the following components in percentage by weight: 10 to 15 percent of elemene serving as an active ingredient, 3 to 15 percent of sustained-release agent, 45 to 70 percent of filling agent, 3 to 8 percent of disintegrating agent, 1 to 10 percent of adhesive and 1 to 8 percent of lubricant. The elemene sustained-release tablets have expansion and adhesion properties, can prolong the residence time of the medicament on the upper middle part of the gastrointestinal tract, can be taken twice every day with 3 tablets each time, and fulfills the purposes of reducing blood concentration fluctuation, keeping effective blood concentration for long time and reducing stimulation to the gastrointestinal tract. The skeleton-type sustained-release preparation has low cost, is easy to control and is favorable for industrialized production.
Description
technical field The invention relates to an anticancer drug elemene sustained-release tablet and a preparation method thereof. Background technique Elemene (Elemene) is a natural medicine with anticancer activity extracted from the rhizome of Zingiberaceae plant Wenyujin (also known as Wenyujin) in my country. It is a new type of anticancer drug. Elemene is widely found in many kinds of traditional Chinese medicines, such as ginseng, Atractylodes macrocephala, cloves, chrysanthemum frondosa, chrysanthemum multispike, myrrh, windproof and other Chinese herbal medicines. Elemene chemical name: 1-methyl-1-vinyl-2,4-diisopropenylcyclohexane, molecular formula: C 15 h 24 . Elemene contains four isomers: α-elemene, β-elemene, γ-elemene and δ-elemene, and the main component is β-elemene. The chemical structural formula of elemene is as follows: The preparation method of elemene has been reported in many documents, one is to extract and refine from plants such as zedoary, or d...
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/015A61K47/38A61P35/00
CPCA61K36/00A61K9/2018A61K31/015A61K9/2009A61K9/2059A61K9/2054A61P35/00
Inventor 谢恬范海珠展晓日李铖璐曾昭武
Owner 谢恬
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