Method for preparing veterinary injection of spectinomycin hydrochloride and lincomycin hydrochloride

Abstract

The invention relates to a method for preparing veterinary injection of spectinomycin hydrochloride and lincomycin hydrochloride. The spectinomycin hydrochloride is coated by cyclodextrin to form an inclusion compound, and then the inclusion compound is prepared into compound injection with the lincomycin hydrochloride. The stability of the injection of the spectinomycin hydrochloride and the lincomycin hydrochloride prepared by the method is obviously higher than that of the injection prepared by a conventional method; the injection completely meets the requirements of the quality standard of the injection; and clinical experiments show that the treatment effect of the injection is obviously better than that of the injection prepared by the conventional method. The preparation method of the invention breaks through the key technical difficulty of the compound injection of the spectinomycin hydrochloride and the lincomycin hydrochloride so as to ensure good quality and medicament effect of the product, and can provide a medicament with stable quality and clear treatment effect for clinically treating infections of livestock and poultry bacteria, mycoplasma and the like through veterinarians.

Description

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AI Technical Summary

Benefits of technology

This patented technology solves two issues: firstly, while treating peptidogens like streptococcic acid or lincosamine hydrocholorides (which are commonly used antibiotics) with cyclodeshydrodecaprone sulfate-containing substances, resulting in their instability during storage at room temperature; secondly, making them difficult to administer directly without further manipulation due to its poor solubility characteristics when mixed with other medications that require dissolution before administration. These new methods improve both these factors leading to improved results over existing techniques.

Problems solved by technology

This patents discusses different ways to prepare stabilized pefimomicmycin hydrocodone with improved pharmacokinetic properties compared to existing products containing either lithium ionophoreceptor agonists like cladinosyn A/B monotherapy against streptocalcocea fevers due to their high resistance towards gram positive bactrummicrobons. However, these agents may be associated with adverse reactions including nephrotoxicosis and hemolytic uremism when given through this route. To address this problem, researchers developed various methods called synthecrolase IV(SSI), which specifically targets certain types of DNA damage involved in animal disease outbreaks. These techniques include injectable formulations and solid dosage forms, making them suitable for target therapy purposes.

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