Absorption film for eliminating bilirubin and preparation method thereof

An adsorption film and bilirubin technology, applied in the field of biomedical materials, can solve the problem that bilirubin molecules are difficult to be removed, and achieve the effects of improving biocompatibility, controllable deposition amount, and strong scalability
CN101862610AInactive Publication Date: 2010-10-20DALIAN UNIV OF TECH
2 Cites 17 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2010-10-20
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention discloses an absorption film for eliminating bilirubin in blood and a preparation method thereof, and belongs to the technical field of biomedical materials. The method is characterized in that: a modifying method that chitosan is deposited on a hollow fiber film support layer and an outer surface of a hemodialyzer, and the chitosan is coupled with aglucon which can be interacted with the bilirubin is adopted; the coupled aglucon comprises polymine, polylysine, aminoethanol, 2,3-epoxypropyltrimethylammonium chloride, 3-chloro-2-hydroxypropltrimethyl ammonium chloride, betaine, lysine, arginine, dye Cibacron Blue F3GA, K-GRS blue, caprylaldehyde, n-butylamine, aniline, beta-cyclodextrin, bovine serum albumin and human sreum albumin. The method has the advantages of simple operation, mild condition, no damage to the structure of the film per se, capability of being coupled with various aglucons according to requirement and strong expansibility. When the absorption film is used for eliminating bilirubin, the bilirubin can be removed by the conventional dialysis with a simple system and low operation pressure.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a method for preparing an adsorption film for removing fat-soluble toxin bilirubin in the treatment of hyperbilirubinemia. Background technique

[0002] Abnormal bilirubin metabolism can lead to a large accumulation of bilirubin in the body and become an endogenous toxin, which can cause symptoms such as jaundice, liver and biliary tract dysfunction and brain damage, and quickly and effectively remove excess bilirubin in the blood Can relieve the patient's symptoms.

[0003] Currently, hemoperfusion is the main way to remove bilirubin clinically.

[0004] Blood / plasma perfusion (Hemoperfusion, HP) is to introduce the patient's blood / plasma into a perfusion device equipped with a solid adsorbent, and use the special pore structure of the adsorbent to absorb and remove bilirubin. At present, the bilirubin adsorption materials widely used in clinic mainly ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More