Absorption film for eliminating bilirubin and preparation method thereof

An adsorption film and bilirubin technology, applied in the field of biomedical materials, can solve the problem that bilirubin molecules are difficult to be removed, and achieve the effects of improving biocompatibility, controllable deposition amount, and strong scalability

Inactive Publication Date: 2010-10-20
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hemodialysis is basically ineffective for removing bilirubin, because bilirubin is strongly bound to albumin molecules in the blood, and it is difficult to remove bilirubin molecules during ordinary dialysis

Method used

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  • Absorption film for eliminating bilirubin and preparation method thereof
  • Absorption film for eliminating bilirubin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Using polyethyleneimine as the ligand of the adsorption film and the scavenging experiment on bilirubin, the steps are as follows:

[0019] The first step, the preparation of the adsorption membrane

[0020] A) Deposition of Chitosan

[0021] 1. 1% acetic acid solution containing chitosan 0.2g circulates outside the hollow fiber membrane (hemodialyzer outer chamber), controls ultrafiltration, and the ultrafiltration flow rate is 10ml / min, to remove a part of acetic acid in the chitosan solution or small molecules such as hydrochloric acid and water, and at the same time make chitosan fully adhere to the surface of the hollow fiber membrane.

[0022] 2. Change the pH of the inner and outer sides of the hollow fiber membrane to 12 to fully deposit chitosan.

[0023] B) Coupling ligand

[0024] The chitosan-deposited hollow fiber membrane was reacted with 1% glutaraldehyde solution at pH=8.0 at 40°C for 12h. After washing to remove free glutaraldehyde, react with 5% po...

Embodiment 2～16

[0029] Using different ligands to prepare adsorption membranes and scavenging experiments on bilirubin, the steps are the same as in Example 1, and the specific operating parameters and experimental results are shown in the following table:

[0030] implement

example

Chitosan

volume percentage

(%)

Acetic acid solution

liquid concentration

(m / v)

Ultrafiltration flow rate

(ml / min)

ultrafiltration

time

(min)

deposition

pH

Ligand

Bilirubin

initial concentration

(mg / L)

Removal rate

2

0.5

0.5％

20

30

13

Polylysine

226.07

35.45％

3

0.5

0.5％

0.5

60

10

aminoethanol

253.15

16.14％

4

1.0

2.0％

5

50

13

2,3-Epoxypropyltri

Methyl ammonium chloride

233.52

26.27％

5 ...

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PUM

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Abstract

The invention discloses an absorption film for eliminating bilirubin in blood and a preparation method thereof, and belongs to the technical field of biomedical materials. The method is characterized in that: a modifying method that chitosan is deposited on a hollow fiber film support layer and an outer surface of a hemodialyzer, and the chitosan is coupled with aglucon which can be interacted with the bilirubin is adopted; the coupled aglucon comprises polymine, polylysine, aminoethanol, 2,3-epoxypropyltrimethylammonium chloride, 3-chloro-2-hydroxypropltrimethyl ammonium chloride, betaine, lysine, arginine, dye Cibacron Blue F3GA, K-GRS blue, caprylaldehyde, n-butylamine, aniline, beta-cyclodextrin, bovine serum albumin and human sreum albumin. The method has the advantages of simple operation, mild condition, no damage to the structure of the film per se, capability of being coupled with various aglucons according to requirement and strong expansibility. When the absorption film is used for eliminating bilirubin, the bilirubin can be removed by the conventional dialysis with a simple system and low operation pressure.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a method for preparing an adsorption film for removing fat-soluble toxin bilirubin in the treatment of hyperbilirubinemia. Background technique [0002] Abnormal bilirubin metabolism can lead to a large accumulation of bilirubin in the body and become an endogenous toxin, which can cause symptoms such as jaundice, liver and biliary tract dysfunction and brain damage, and quickly and effectively remove excess bilirubin in the blood Can relieve the patient's symptoms. [0003] Currently, hemoperfusion is the main way to remove bilirubin clinically. [0004] Blood / plasma perfusion (Hemoperfusion, HP) is to introduce the patient's blood / plasma into a perfusion device equipped with a solid adsorbent, and use the special pore structure of the adsorbent to absorb and remove bilirubin. At present, the bilirubin adsorption materials widely used in clinic mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/82B01D69/08B01D67/00A61M1/18A61M1/34
Inventor 贾凌云徐文学韦厚良王智谢键
Owner DALIAN UNIV OF TECH
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