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Artificial eardrum using silk protein and method of fabricating the same

An artificial tympanic membrane and silk protein technology, which can be used in prostheses, ear implants, tissue regeneration, etc., and can solve problems such as inflammation

Active Publication Date: 2010-11-10
IND ACADEMIC COOP FOUND HALLYM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used paper patches are known to treat chronic perforated eardrums, but they can cause inflammation

Method used

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  • Artificial eardrum using silk protein and method of fabricating the same
  • Artificial eardrum using silk protein and method of fabricating the same
  • Artificial eardrum using silk protein and method of fabricating the same

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Embodiment Construction

[0031] Embodiments of the present invention will now be described in detail with reference to the accompanying drawings. However, it should be understood that the present invention is not limited to the embodiments but includes various modifications, equivalent changes, and substitutions. The embodiments of the present invention are provided in order to more fully explain the present invention to those skilled in the art.

[0032] First, the artificial tympanic membrane using the silk protein of the present invention is an artificial biomembrane that is manufactured using silk material and can be used for acute and chronic tympanic membrane perforation. The artificial eardrum may include an artificial biomembrane using silk and a patch for the eardrum.

[0033] figure 1 is a silk membrane for an artificial eardrum using silk protein and a fractured surface thereof according to an embodiment of the present invention, and figure 2 is a tensile strength curve of a silk membra...

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PUM

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Abstract

Provided are an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

Description

[0001] Cross References to Related Applications [0002] This application claims priority and benefit from Korean Patent Application No. 2009-0040200 filed on May 8, 2009, the disclosure of which is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to an artificial eardrum using silk protein and a manufacturing method thereof, and more particularly, to an artificial eardrum in the form of a silk membrane using silk protein using silk protein obtained by removing sericin from silkworm cocoons or its Composite made as a raw material for the artificial eardrum that stimulates the regeneration of the eardrum perforated by disease or sudden accident, provides a clear boundary for the regenerated eardrum and is easy to use due to high biocompatibility and transparency ; and a method of manufacture thereof. Background technique [0004] Generally speaking, silk is a fabric made from cocoons formed by spinning silkworms fed wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/18A61L27/22A61L27/44A61L27/54A61L27/24A61L27/20A61L27/18A61L27/16A61L27/38
CPCA61F2/18A61L27/3641A61F11/00A61L2430/14A61L27/38A61L27/3604A61F2002/183A61L27/22
Inventor 朴灿钦金珍金春会权海龙李光吉姜锡宇吕奏洪赵柳英禹顺玉韩相美
Owner IND ACADEMIC COOP FOUND HALLYM UNIV
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