Application of determination of anti-M3 receptor altered peptide antibody in diagnosis of sjogren syndrome

Abstract

The invention provides an M3 receptor altered peptide and an analogue thereof, which are used for detecting the sjogren syndrome. An antigen of the altered peptide can be specifically combined with a specific antibody in a patient with the sjogren syndrome, thereby having very high sensitivity and specificity.

Description

Application of Anti-M3 Receptor Allosteric Peptide Antibody Determination in Diagnosis of Sjögren's Syndrome technical field The invention relates to the preparation of cholinergic M3 type receptor allosteric peptide and its application as antigen in detecting Sjögren's syndrome and other diseases. 1. Background technology Sjogren's syndrome (Syndrome, SS) is a systemic autoimmune disease characterized by invasion of exocrine glands such as lacrimal glands and salivary glands. The most common clinical manifestations of the disease are dry eyes and dry mouth, and can involve the lungs, kidneys, lymphatic system, blood vessels and liver and other organs. The disease has no obvious regional distribution difference, and can occur at any age, with 40-60 years old, especially postmenopausal women in the majority, and the ratio of male to female is 1:9. The prevalence rate in my country is 0.77%, and the prevalence rate in the elderly population is as high as 4%. There are nearl...

AI Technical Summary

Problems solved by technology

At present, no ideal serological diagnosis method has been found clinically. In addition to clinical symptoms, the diagnosis is mainly made by invasive examinations

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