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Traditional Chinese medicine astragalus polysaccharide immunopotentiator

The technology of an immune enhancer and stilbene sugar is applied in the field of livestock and poultry immune adjuvants, and achieves the effects of refined prescription, no hidden dangers of drug residues and improved efficacy.

Active Publication Date: 2010-11-17
NANJING AGRICULTURAL UNIVERSITY
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Problems solved by technology

[0003] Technical Problems The present invention aims at the urgent need for efficient and safe immune enhancers or vaccine adjuvants in the current animal disease prevention and control technology, and provides a new type of traditional Chinese medicine immune enhancer made of astragalus extract and sulfated epimedium polysaccharide agent

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  • Traditional Chinese medicine astragalus polysaccharide immunopotentiator
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Embodiment Construction

[0015] 1. Preparation process

[0016] (1) Preparation of Radix Astragali Extract Taking the yield of Astragalus polysaccharides in the extract as an index, the amount of water added, the extraction time, and the number of extractions were carried out in an orthogonal experiment to determine that the optimal extraction process of the Radix Astragali extract was to add 10 times of water and boil 60min, extraction 3 times. Take 40g of astragalus decoction pieces, decoct in water according to the above process, combine the filtrates, concentrate under reduced pressure at 85°C to 500ml, and obtain the astragalus extract solution.

[0017] (2) Extraction of Epimedium polysaccharides Taking the yield of Epimedium polysaccharides as an index, the amount of water added, the boiling time and the number of extractions were carried out by orthogonal experiments, and the optimum extraction process of Epimedium polysaccharides was determined to be adding 20 times of water, Decoction 2 tim...

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Abstract

The invention relates to a traditional Chinese medicine immunopotentiator (an astragalus polysaccharide immunopotentiator for short) prepared from astragalus extracts and sulfated epimedium polysaccharides, which belongs to the field of immunological adjuvants of livestock and poultry. 1,000ml of the liquid medicine is prepared from 40g of astragalus and 120g of epimedium herb. The preparation method of the immunopotentiator comprises the following steps of: decocting the astragalus with water for three times, then merging the obtained filter liquor and condensing the filter liquor into 500ml of astragalus solution; extracting the epimedium polysaccharides by using the epimedium herb water decoction and ethanol precipitate method, then decorating the polysaccharides by using the chlorosulfonic acid-pyridine method, and preparing the polysaccharides into 500ml of sulfated epimedium polysaccharide solution after carrying out distilled water dialysis on the polysaccharides; and mixing the astragalus solution and the sulfated epimedium polysaccharide solution, and then filtering, sub-packaging and sterilizing to obtain the traditional Chinese medicine astragalus polysaccharide immunopotentiator. The immune experiment shows that the astragalus polysaccharide immunopotentiator has the advantage of obviously improving the proliferation of peripheral blood lymphocyte of chicken and enhancing the cellular immunity, obviously improving the potency of a serum antibody, promoting the lymphocyte proliferation, enhancing the cellular immunity and humoral immunity, and improving the immune response of a vaccine by coordinately immunizing chickling by using the Newcastle disease vaccine.

Description

1. Technical field [0001] The invention is a traditional Chinese medicine immune enhancer made of astragalus extract and sulfated epimedium polysaccharide, referred to as Qihuotang immune enhancer for short, and belongs to the field of livestock and poultry immune adjuvants. 2. Background technology [0002] Livestock and poultry infectious diseases have always been the primary problem that endangers the development of animal husbandry, especially the major viral infectious diseases that are currently prevalent. So far, there is no effective treatment method, and vaccine prevention is still the most important measure. Due to various reasons, most vaccines can only exert a good anti-epidemic effect if they are used in conjunction with immune enhancers or immune adjuvants. However, chemical immune adjuvants such as oil emulsions and aluminum gels widely used at home and abroad often have disadvantages such as large side effects, strong local irritation, carcinogenicity, troubl...

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Application Information

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IPC IPC(8): A61K39/39
Inventor 胡元亮王德云郭利伟刘家国张宝康
Owner NANJING AGRICULTURAL UNIVERSITY
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