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Preparation method for protective agent of intestinal mucosal barrier

A protective agent, the technology of intestinal mucosa, applied in the field of preparation of intestinal mucosal barrier protective agent, can solve the problems of difficulty in mass promotion and application, unstable effect, insignificant effect, etc., achieves convenient use, maintains normal barrier, and improves daily weight gain. and feed conversion efficiency

Inactive Publication Date: 2010-12-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Above-mentioned technology can alleviate " piglet weaning syndrome " to a certain extent, but effect is not obvious, and effect is inaccurate, and exists easy inactivation (prebiotic), unstable effect (prebiotic), expensive (glutamine, Nucleotides, epidermal growth factor) and other issues, it is still difficult to popularize and apply in large quantities in production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The preparation method of intestinal mucosa barrier protection agent comprises the following steps:

[0022] 1) take silica gel and butyric acid by weight ratio of silica gel: butyric acid=1: 1~2;

[0023] 2) diluting butyric acid into an aqueous solution with a volume percentage of 10% to 80%;

[0024] 3) Slowly add silica gel into the butyric acid aqueous solution in step 2) under stirring, keep stirring, and react at room temperature for 1 to 10 hours;

[0025] 4) filter the reaction solution in step 3) to obtain a filter cake;

[0026] 5) Take the stearate according to the weight ratio of silica gel: stearate=1:0.2~1.0, and use the single-screw mixer or twin-screw mixer to stir and mix the stearate and the filter cake obtained in step 4) After 0.5 to 5 hours, the obtained mixture is dried and pulverized to a size larger than 300 mesh to obtain an intestinal mucosal barrier protection agent.

[0027] The chemical structure general formula of described silica gel i...

Embodiment 1

[0031] 1) The bulk density is 0.2g / ml, the particle size is 100μm, and the specific surface area is 200m 2 / g, pore volume 1.0ml / g, the silica gel of aperture 8nm, by silica gel: the weight ratio of butyric acid=1: 1.2 takes by weighing silica gel and butyric acid;

[0032] 2) diluting butyric acid into a 10% aqueous solution by volume;

[0033] 3) Slowly add silica gel to the butyric acid aqueous solution in step 2) under stirring, continue to stir, and react at room temperature for 0.5 hours;

[0034] 4) filter the reaction solution in step 3) to obtain a filter cake;

[0035] 5) take sodium stearate by weight ratio of silica gel: sodium stearate=1:0.2, sodium stearate is mixed with the filter cake obtained in step 4) for 2 hours, and the resulting mixture is dried and pulverized to greater than 300 meshes to obtain the intestinal mucosal barrier protective agent.

[0036] Select 120 piglets of 28 ± 1 day old with an average weight of 7.65 ± 0.3kg "Du Changda" piglets, ac...

Embodiment 2

[0042] 1) The bulk density is 0.5g / ml, the particle size is 10μm, and the specific surface area is 800m 2 / g, silica gel with a pore volume of 2.0ml / g and a pore diameter of 45nm. By silica gel: butyric acid=1:2 weight ratio takes by weighing silica gel and butyric acid;

[0043] 2) diluting butyric acid into an 80% aqueous solution by volume;

[0044] 3) Slowly add silica gel to the butyric acid aqueous solution in step 2) under stirring, continue to stir, and react at room temperature for 5 hours;

[0045] 4) filter the reaction solution in step 3) to obtain a filter cake;

[0046] 5) take calcium stearate by weight ratio of silica gel: calcium stearate=1: 1.0, calcium stearate is mixed with the filter cake of step 4) gained for 5 hours, the mixture of gained is oven-dried, pulverizes to greater than 300 meshes to obtain the intestinal mucosal barrier protective agent.

[0047] Select 240 male-female mixed chicks from healthy Avian commercial products, and randomly divid...

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Abstract

The invention discloses a preparation method for a protective agent of an intestinal mucosal barrier. Butyric acid is absorbed or bonded on a silica gel surface or in a hole by using silica gel; and after being stirred and mixed, synthesized silica gel loading butyric acid and stearate are dried and pulverized. Because of having the characteristics of high surface activity, microporous structure and large specific surface area, the silica gel has good biocompatibility and intestinal mucosal affinity and a function of controlling slow release for the loaded butyric acid. In addition, the stearate reacts with the silica gel loading butyric acid in the process of stirring and mixing to generate byterate, and the stearate has an envelope function to add the storage stability of a product. The protective agent of the intestinal mucosal barrier can repair and protect intestinal epithelial cells, maintain the normal barrier of the intestinal mucosa and beneficial microorganism of the intestinal mucosa, and enhance health level of animals, daily gain and feed conversion efficiency.

Description

technical field [0001] The invention relates to a preparation method of an intestinal mucosa barrier protection agent. Background technique [0002] To ensure good production performance of livestock and poultry, health is the necessary support platform, and the primary focus of livestock and poultry health is the health of the gastrointestinal tract. The only way to obtain various nutrients required by livestock and poultry is the gastrointestinal tract. The gastrointestinal tract is directly connected with the outside world, and it is the front line against external pathogenic infection and also one of the main battlefields. It is not difficult to see that the health and normal function of the gastrointestinal tract are of great significance to livestock and poultry production. Since the gastrointestinal tract of livestock and poultry is highly open to the outside world, various conditions of the external environment and changes in the stability of the internal environment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/14A61K47/04A61K31/19A23K1/16A61P1/00A23K20/105A23K20/20A23K50/10A23K50/30A23K50/60A23K50/75
Inventor 胡彩虹钱仲仓朱康左安燕夏枚生
Owner ZHEJIANG UNIV
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