The invention discloses a reverse design method for an impeller of a centrifugal pump, which comprises the following steps: according to a given impeller axial plane, a blade in a three-dimensional space can be actually expressed as X=X(z(u, v), r(u, v), theta(u, v)), the (z(u, v), r(u, v)) has been determined when a streamline of the impeller axial plane is given, and the space modeling of the blade can be determined by determining the theta(u, v) on the impeller axial plane. The reverse design method is characterized in that the reverse design method transforms a geometric design problem of the blade of the centrifugal pump into a boundary value problem of a partial differential equation to solve under the condition of the given impeller axial plane of the centrifugal pump. The reverse design method overcomes a lot of disadvantages such as the definition and modification of geometrical shape of the blade in the prior design method, can realize the parametric design of the blade, overcome the defects existing when a fussy two-dimensional form drawing is used for showing three-dimensional twisted blades in the prior method, can closely combine the hydraulic design of hydraulic machinery, three-dimensional solid modeling and the CFD analysis of flow field, and realize the quick and accurate solving of the reverse problem of the blade.