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In-situ gel preparation of potassium dehydroandrographolide succinate and preparation method thereof
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A technology of in-situ gel and tranexine, which is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, antiviral agents, etc., to achieve the effect of significant medicinal effect, stable properties and good antipyretic effect.
Active Publication Date: 2012-08-22
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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Embodiment 1
[0027] Prescription: Chuanhuning 30.0g, poloxamer 40719.0g, poloxamer 1886.0g, sodium benzoate 0.5g, appropriate amount of triethanolamine, distilled water to make up to 100g.
[0028] Preparation method: Dissolve the prescribed amount of sodium benzoate in an appropriate amount of distilled water, add the prescribed amount of Chuanhuning, adjust the pH to about 5.8, and obtain Chuanhuning water; take the prescribed amount of poloxamer 188, put it in the Chuanhuning aqueous solution, and stir to dissolve at room temperature , then add the prescribed amount of poloxamer 407, stir to disperse evenly, refrigerate in a refrigerator at 4°C for more than 48 hours to obtain a yellow and clear solution, adjust the pH to 5.8-6.2, add water to make it 100g, and fill it.
Embodiment 2
[0030] Prescription is the same as embodiment 1
[0031] Preparation method: Take the prescribed amount of sodium benzoate, poloxamer 188, and poloxamer 407, put them in an appropriate amount of distilled water, stir to disperse evenly, and refrigerate in a refrigerator at 4°C for 24 hours to obtain a transparent glue, add the prescribed amount of Chuanhuning, Adjust the pH to 5.8-6.2, add water to make 100g, fill it, and get ready.
Embodiment 3
[0033] Prescription: Chuanhuning 10g, poloxamer 40720.0g, poloxamer 1881.0g, hydroxypropyl β-cyclodextrin 6.0g, sodium benzoate 0.5g, triethanolamine amount, distilled water to make up to 100g.
[0034] Preparation method: Dissolve 6.0 g of sodium benzoate and 6.0 g of hydroxypropyl β-cyclodextrin in the prescribed amount of distilled water, and the remaining operating steps and methods are the same as in Example 2.
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Abstract
The invention relates to an in-situ gel preparation of potassium dehydroandrographolide succinate and a preparation method thereof. The preparation is prepared from potassium dehydroandrographolide succinate (dehydration andrographolide butanedioic acid ester single sylvite half), in-site gel substrates recognized in the field, and other pharmaceutic adjuvants necessary for other pharmacy by using water as a solvent. In-situ gel of potassium dehydroandrographolide succinate is liquid freely moving outside a body, and forms semisolid gel after patients take the gel. The invention has the advantages of definite effect, stable performance, simple preparation, convenient administration, strong compliance for patients, no toxic and side effect, no untoward effect, high bioavailability, and on the like. The in-situ gel preparation has good antipyretic and antiinflammatory action, can be used for clinically treating viral respiratory tract infection and viral pneumonia, can be used as alternative medicine for potassium dehydroandrographolide succinate injection, and is particularly suitable for infants and patients who have trouble in taking medicine.
Description
Technical field: [0001] The invention belongs to the field of traditional Chinese medicine, and more specifically relates to a Chuanhuning in situ drug with good antipyretic effect and anti-inflammatory effect, which is the first choice for viral upper respiratory tract infection and viral pneumonia, especially for infants and patients who are inconvenient to take medicine. Gel formulation and method for its preparation. Background technique: [0002] In recent years, with the large-scale clinical application of traditional Chinese medicine injections, the problem of adverse reactions has become more and more prominent. The 10 varieties of leaf saponin sodium, puerarin and zedoary oil injection were more serious, and their adverse reaction rate accounted for 74.4% of all traditional Chinese medicine injections. Incidents of anaphylactic shock and acute death caused by adverse reactions of traditional Chinese medicine injections have been reported from time to time (Zuo Zhiy...
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