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Chloroplast-derived human vaccine antigens against malaria

A malaria and vaccine technology, applied in the field of infectious diseases, can solve problems such as blocking

Inactive Publication Date: 2011-01-19
UNIV OF CENT FLORIDA RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even though AMA-1 exhibits high polymorphism, the C-terminal region is highly conserved and can be blocked by inhibitory antibodies

Method used

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  • Chloroplast-derived human vaccine antigens against malaria
  • Chloroplast-derived human vaccine antigens against malaria
  • Chloroplast-derived human vaccine antigens against malaria

Examples

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Embodiment Construction

[0073] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0074]The invention will now be described in more detail hereinafter with reference to the accompanying drawings, in which preferred embodiments of the invention are shown. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. Any publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including any definitions, will control. In addition, the materials, methods, and examples given are exemplary only in nature and not limiting. Accordingly, this invention may be embodied in ...

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Abstract

Disclosed is a method of making a malaria vaccine, the method comprising stably transforming a plant by inserting into its plastid genome a nucleic acid sequence encoding and operable to constitutively express a malaria antigenic polypeptide selected from AMA-1, MSP-1 or both; harvesting the stably transformed plant in whole or in part; purifying the expressed malaria antigenic polypeptide from the harvested plant; and packaging the purified antigenic polypeptide under sterile conditions in an amount for a predetermined dosage. Also disclosed is an oral vaccine effective in raising malaria antibodies in a susceptible host, the vaccine comprising leaf material from an edible plant containing plastids stably transformed to constitutively express a fusion polypeptide consisting essentially of cholera toxin B subunit and a malaria antigenic polypeptide selected from AMA-1, MSP-1 or both.

Description

[0001] Statement of Government Rights [0002] The invention claimed herein was made, at least in part, with United States Government support. Accordingly, the government may have certain rights in this invention as provided by law. [0003] related application [0004] This application claims the benefit of U.S. Provisional Application Serial Nos. 60 / 984,111, filed October 31, 2007, 61 / 057,442, filed May 30, 2008, and 61 / 091,458, filed August 25, 2008, all of which Incorporated herein in its entirety by reference. field of invention [0005] The present invention relates to the field of infectious diseases, and more particularly to the vector-borne disease malaria and immunogenic malaria antigens expressed in plants. Background of the invention [0006] Malaria is a vector-borne protozoan disease. Four distinct species of Plasmodium affect humans (P. falciparum, P. vivax, P. malariae, and P. ovale) ), Plasmodium falciparum is the most virulent species, responsible for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/15
CPCA61K2039/55544A61K39/015A61K2039/517C12N15/8258A61K2039/542A61P33/06Y02A50/30
Inventor D·亨利D·查克拉巴蒂
Owner UNIV OF CENT FLORIDA RES FOUND INC
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