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Application of physcion in preparing medicines for treating depression

A technology of emodin methyl ether and depression, which is applied in the application field of preparing products for treating depression, and can solve the problems of high price, toxic and side effects, etc.

Inactive Publication Date: 2012-02-01
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), all of which have different degrees of toxic and side effects and are expensive. Therefore, it is of great theoretical and practical significance to develop new antidepressants from traditional Chinese medicine.

Method used

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Embodiment Construction

[0007] The present invention will be further described below in conjunction with embodiment.

[0008] The following animal experiment is a further detailed description of the present invention, but does not imply any limitation to the present invention. Obviously, the broadness of the pharmacological feasibility of the selected experimental animals expresses the animal groups to which the application of the present invention should be traced.

[0009] Experimental animals: male Kunming mice, weighing 18g-30g at the beginning of the test, purchased from the Sichuan Provincial Medical Experimental Animal Center, certificate number: SCXK[Sichuan] 2008-14, received 12h light / 12h dark every day, and the light cycle was 8: From 00 to 20:00, the laboratory temperature is 20±2°C, and the humidity is 60%. Animals can ingest standard feed and clean water by themselves. Animal experiments comply with international experimental animal ethics requirements.

[0010] drug:

[0011] Emodin ...

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Abstract

The invention discloses application of physcion used as an active component in preparing medicines for treating depression. The physcion has the characteristic of little toxicity, and can be used for preparing medicines for preventing or treating various kinds of depression, including endogenous depression, reactive depression, masked depression, secondary depression caused by medicines, climacteric depression or postpartum depression, depression induced by cerebral trauma or cerebrovascular disorder and depressive neurosis as well as diabetes companied by depression and related diseases.

Description

technical field [0001] The invention belongs to medicine, especially the new medicine application of emodin methyl ether extracted from natural plants, and specifically relates to their application in preparing products for treating depression. Background technique [0002] Emodin (physcion) is an anthraquinone compound, also known as cinnabar B, festerone, molecular formula C 16 h 12 o 5 , the chemical name is 1,8-dihydroxy-3-methoxy-6-methylanthraquinone. It is the most widely distributed anthraquinone substance, widely present in many plants of Polygonaceae, Fabaceae, Labiatae, Compositae, Orchidaceae and Rosaceae. Emodin is also contained in traditional Chinese medicines such as 蔹, Digupi, Liaogewang and Xiangfu. Emodin methyl ether is mainly extracted from the Chinese herbal medicines Polygonaceae rhubarb, Polygonum cuspidatum and Polygonum multiflorum, and leguminous cassia. In recent years, a large number of in-depth studies on the pharmacological mechanism of e...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P25/24A61P25/28
Inventor 吴晓青马超英童妍耿耘陈晓珍
Owner SOUTHWEST JIAOTONG UNIV
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