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Application of emodin in preparation of drugs for treating depression

A technology of depression and emodin, which is applied in the field of preparation of products for the treatment of depression, can solve the problems of high price, toxic and side effects, etc.

Inactive Publication Date: 2012-03-28
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), all of which have different degrees of toxic and side effects and are expensive. Therefore, it is of great theoretical and practical significance to develop new antidepressants from traditional Chinese medicine.

Method used

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Embodiment Construction

[0007] The present invention will be further described below in conjunction with embodiment.

[0008] The following animal experiment is a further detailed description of the present invention, but does not imply any limitation to the present invention. Obviously, the broadness of the pharmacological feasibility of the selected experimental animals expresses the animal groups to which the application of the present invention should be traced.

[0009] Experimental animals: male Kunming mice, weighing 18g-22g at the beginning of the test, purchased from the Sichuan Provincial Medical Experimental Animal Center, certificate number: SCXK[Sichuan] 2008-14, received 12h light / 12h dark every day, and the light cycle was 8: From 00 to 20:00, the laboratory temperature is 20±2°C, and the humidity is 60%. Animals can ingest standard feed and clean water by themselves. Animal experiments comply with international experimental animal ethics requirements.

[0010] drug:

[0011] Emodin ...

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PUM

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Abstract

The invention discloses an application of emodin as an active ingredient in the preparation of medicines for treating depression, wherein the emodin is used as an active ingredient to prepare medicines for treating the depression. The invention provides an application of the emodin as an active ingredient in the production of medicines for preventing and treating the depression. Emodin has the characteristic of low toxicity and is used for preparing medicines for preventing or treating various kinds of depression symptoms comprising endogenous depression, reactive depression, secretiveness depression, medicine induced secondary depression, climacteric or postpartum depression, cerebral trauma or cerebral apoplexy induced depression and depressive neurosis, and can also be applied to medicines for treating diabetes accompanied by depression and related diseases.

Description

technical field [0001] The invention belongs to medicine, especially the new medicine application of emodin extracted from natural plants, and specifically relates to their application in preparing products for treating depression. Background technique [0002] Emodin is a derivative of hydroxyanthraquinone, its molecular formula is C15H10O5, and its chemical name is 6-methyl-1,3,8-trihydroxyanthraquinone. It is one of the most widely distributed anthraquinones, found in many molds, lichens, higher plants and insects. Emodin is an active ingredient isolated from traditional Chinese medicines such as Rhubarb, Polygonum, Rhamna and Senna, and widely exists in the rhizome of Rhubarb, the bark and root bark of Rhamna, and the seeds of Cassia. Emodin is one of the active components of rhubarb, and accounts for a relatively large proportion of free anthraquinone in genuine rhubarb (0.01% in Rhubarb palmatum, Rpalmatum vartanguticum in Rhubarb tangut, and Roffieinale in medicinal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P25/24
Inventor 吴晓青陈晓珍童妍马超英刘睿颖
Owner SOUTHWEST JIAOTONG UNIV
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