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Use of a stilbene compound in the preparation of drugs for the prevention and treatment of depression

A technology for depression and drugs, applied in the direction of active ingredients of hydroxyl compounds, drug combinations, pharmaceutical formulas, etc., can solve problems such as large side effects, ineffective clinical treatment, and difficult to control addiction

Active Publication Date: 2016-02-24
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the use of helexin and its derivatives, naringin, 7-O-β-D-acetylated sugar-coumarin, emodin methyl ether, etc. in the treatment of depression drugs has also been developed in recent years, However, there are still some deficiencies in clinical treatment effects, such as insignificant clinical effects, large side effects, and difficulty in controlling addiction.

Method used

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  • Use of a stilbene compound in the preparation of drugs for the prevention and treatment of depression
  • Use of a stilbene compound in the preparation of drugs for the prevention and treatment of depression
  • Use of a stilbene compound in the preparation of drugs for the prevention and treatment of depression

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0027] Experimental Example 1: Toxicity Test

[0028] 1. Materials

[0029] 1.1 Drugs: Trizastilbene and piceatanol were prepared by Kunming Pharmaceutical Group Co., Ltd., and the purity was greater than 98.0% after testing, and they were stored in a desiccator.

[0030] 1.2 Animals: healthy Kunming mice, both male and female, weighing 18-22g, provided by Kunming Pharmaceutical Group Co., Ltd., license number: SCXK (Dian) 2009-0001.

[0031] , Acute toxicity test in mice

[0032] Under the maximum dosage concentration and maximum dosage volume, the mice were orally administered 1:1 tristilbeside and piceatanol mixed powder 5g / kg, and observed continuously for 14 days. No death or abnormal toxic reaction was found in the experimental mice . It shows that the maximum tolerated dose of trizaperoside and piceatanol administered to mice is 5g / kg.

[0033] , Long-term toxicity test in mice

[0034] The 1:1 mixed powder of tristilbene and piceatanol was divided into three gr...

experiment example 2

[0041] Experimental Example 2: Mouse Tail Suspension Experiment

[0042] 1. Drugs: Trizabetaside and piceatanol were prepared by Kunming Pharmaceutical Group Co., Ltd., and the purity was tested to be greater than 98.0%, and they were stored in a desiccator. During the experiment, 0.9% normal saline was used to make a suspension for later use. Prozac (fluoxetine hydrochloride), Eli Lilly Suzhou Pharmaceutical Co., Ltd.

[0043] 2. Animals: healthy Kunming mice, both male and female, weighing 18-22 g, provided by Kunming Pharmaceutical Group Co., Ltd., license number: SCXK (Dian) 2009-0001.

[0044]3. Method: Healthy Kunming mice were randomly divided into 8 groups, 10 in each group, which were blank control group (normal saline); positive control group (fluoxetine hydrochloride 20.0mg / kg); Picetanol high, medium and low dose groups (30.0, 20.0, 10.0 mg / kg). Oral administration, 1 time / d, for 7 consecutive days. Animals had free access to food and water during the experim...

experiment example 3

[0048] Experiment 3: Forced mice to swim

[0049] 1. Drugs: same as experimental example 2.

[0050] 2. Animals: Same as Experiment 2.

[0051] 3. Method: Healthy Kunming mice were randomly divided into 8 groups, 10 in each group, which were blank control group (normal saline); positive control group (fluoxetine hydrochloride 20.0mg / kg); Picetanol high, medium and low dose groups (30.0, 20.0, 10.0 mg / kg). Oral administration, 1 time / d, for 7 consecutive days. Animals had free access to food and water during the experiment. One hour after the last administration, the mice were placed in a container with a diameter of about 18 cm, a water depth of 18 cm, and a water temperature of 25°C. The swimming time of the mice was 6 minutes. struggling, or the animal appears to be floating with only small limb movements to keep the head above water). The experimental results are shown in Table 2.

[0052] Table 2. Effects on the immobility time of forced swimming in mice (n=10, ±...

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Abstract

The invention discloses the use of a stilbene compound in the preparation of a drug for preventing and treating depression. The stilbene compound is used as an effective active ingredient to manufacture the drug for preventing and treating depression. This type of compound is one or a mixture of trizaperone or piceatanol, and is used for the prevention and treatment of endogenous depression and / or reactive depression and / or masked depression and / or Depression characterized by learning difficulties and / or drug-induced secondary depression and / or medical illness secondary depression and / or postpartum depression and / or menopausal depression and / or depressive neurosis Uses in medicine. The stilbene compound of the present invention can significantly improve the disappointment time of the mouse tail suspension and the immobility time of the forced swimming through the Kunming mouse tail suspension, forced swimming and chronic stress sucrose partiality measurement experiments. The loss of interest symptoms caused by stress has a significant resistance effect, and stilbene compounds have a significant antidepressant effect.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and in particular relates to a new application of a stilbene compound in the preparation of drugs for preventing and treating depression. Background technique [0002] Depression is a common mood disorder, which can be caused by various reasons. The main clinical feature is marked and persistent low mood, and the low mood is not commensurate with the situation. In severe cases, suicidal thoughts and behaviors may appear. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it may become the second largest disease in the world after coronary heart disease, accounting for 15% of the global disease burden. According to expert statistics, patients with depression account for 4-8% of the total population in my country, and more than 800,000 people commit suicide due to depression. [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/05A61P25/24
Inventor 龚云麒陈锦锌刘一丹方芳
Owner KPC PHARM INC
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