New use of sarsasapogenin in medicine for preventing and treating depression

The technology of smilagenin and depression is applied in the field of new use in the prevention and treatment of depression medicine, and can solve the problems of many side effects, easy recurrence, low efficiency and the like

Inactive Publication Date: 2007-08-22
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the treatment of depression is still dominated by drug therapy, but the current an...

Method used

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Embodiment Construction

[0005] The following animal experiment is a further detailed description of the present invention, but does not imply any limitation to the present invention.

[0006] 1. The effect of hopelessness on behavior

[0007] The experimental animals are male Kunming mice, free to eat and drink, with a body weight of 20-24 grams.

[0008] Smilagenin was suspended in 0.5% sodium carboxymethyl cellulose, and administered by intragastric administration for 14 days, once a day.

[0009] The animals were divided into random groups, 12 in each group. One hour after the last administration, the animals were put into a glass jar (25 cm high, 10 cm in diameter) with a water depth of 10 cm, and the water temperature was 24°C. Observe for 6 minutes, and record and compare the immobility time within 4 minutes after each group.

[0010] The test results are expressed as mean ± standard deviation, and statistically processed by t test. The mouse forced swimming test is a classic model of behav...

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Abstract

The present invention provides the new use of sarsasapogenin in medicine for preventing and treating depression. Sarsasapogenin has less toxicity, and obvious effect of remitting hypoomnesia, immune degradation, etc caused by depression. The medicine for preventing and treating depression is prepared with sarsasapogenin or its pharmaceutically acceptable salt, ester, glycoside, etc. and may be used in preventing and treating depression, including endogenous depression, reactive depression, masked depression, etc. It may be also used for mammal.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new application of smilagenin in drugs for preventing and treating depression. Background technique [0002] Depression is an affective disorder, and its incidence is increasing year by year, seriously endangering human physical and mental health. At present, the treatment of depression is still dominated by drug therapy, but the current antidepressants generally have the problems of low effective rate, easy relapse, and many side effects. Therefore, finding and developing ideal antidepressant drugs from natural plants has attracted more and more international attention. [0003] Sarsasapogenin, also known as timosaponin, is a steroidal saponin compound and the main active ingredient of the traditional Chinese medicine Anemarrhena, which can improve learning and memory, lower blood sugar, inhibit platelet aggregation, promote neural precursor cell regeneration, Antioxidant...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K36/8964A61P25/24
Inventor 吴英良任利翔
Owner SHENYANG PHARMA UNIVERSITY
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