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Application of 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside to preparing medicaments for treating depression

A technology of tetrahydroxystilbene and glucoside, applied in the field of medicine, can solve the problems of high price, toxic and side effects, etc.

Inactive Publication Date: 2011-02-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), all of which have different degrees of toxic and side effects and are expensive. Therefore, it is of great theoretical and practical significance to develop new antidepressants from traditional Chinese medicine.

Method used

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Embodiment Construction

[0007] The following examples are further explained to the present invention.

[0008] The following animal experiments are further explained to the present invention, but it does not mean any restrictions on the invention.Obviously, the extensive expression of the selected experimental animal pharmacology expresses the animal groups that should be traced back to the application of the invention.

[0009] Experimental animals: Mine-kunming mice, starting the test weighing 18g-30g, purchased at the Sichuan Medical Experimental Animal Center, SCXK [Sichuan] 2008-14, received 12h light / 12h dark every day, the lighting cycle is 8: 00-20:00, the temperature of the laboratory is 20 ± 2 ℃, and the humidity is 60%. Animals can ingest standard feed and clean water by themselves. Animal experiments comply with international experimental animal ethics requirements.

[0010] drug:

[0011] 2,3,5,4'-tetraxyl-based di-lymyrene-2-O-β-D-glucoside (standard products) is provided by Shanghai Shunbo...

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Abstract

The invention discloses application of 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside to preparing medicaments for treating depression, in particular to application of 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside as an active ingredient to preparing medicaments for treating depression. The invention provides the application of the 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside as the medicaments for treating depression, and the 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside is hardly innoxious and is applied to preparing medicaments for preventing or treating various depression symptoms including endogenous depression, reactive depression, masked depression, secondary depression caused by medicaments, menopausal or post-natal depression, depression induced by traumatic brain injury or brain death and depressive neurosis and medicaments for treating diabetes and depression complications and related diseases.

Description

Technical field [0001] The present invention is a drug, especially the 2,3,5,4'-tetraxy-2-o-β-D-glucoside of 2,3,5,4'-tetraxyl hydroxyrhyl-based on natural plants, which involve them in preparation of treatmentApplication in depression products. Background technique [0002] 2,3,5,4'-tetraxial hydroxygenyl-2-O-β-D-glucoside belong to a dilate ethylene compound, and the molecular formula is C 20 H 22 O 9 EssenceThe di -styrechide in He Shouwu has now become a exclusive indicator of He Shouwu's medicinal materials.In recent years, 2,3,5,4 ’-tetraxy-2-O-β-D-glucosidoside of Two-Shouwu 2,3,5,4’-tetraxyl hydroxyrne-2-O-β-β-D-D-D-D-D-D-D-D-D-β-β-D-D-D-D-D-D-D-D-D-β-β-β-β-β-β-β-β-β-β-β-β-β-β-D-glucosidoside research.Studies have found that 2,3,5,4'-tetraxyl hydroxygenyrene-2-O-β-D-glucoside has many pharmacological effects such as: strong anti-oxidation and clear free radical ability;Role to inhibit tumor growth, and also has strong anti -tonic activity, which may participate in regulat...

Claims

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Application Information

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IPC IPC(8): A61P25/28A61P25/24A61K31/7032
Inventor 吴晓青童妍陈晓珍马超英耿耘
Owner SOUTHWEST JIAOTONG UNIV
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