Method for preparing core-shell type composite microspheres by supercritical fluid technology

A supercritical fluid and composite microsphere technology is applied in the direction of making medicines into special physical or ingestible devices, which can solve the problems of high-pressure pump check valve damage and difficulty in implementation, so as to improve the slow-release effect, The effect of improving drug encapsulation efficiency

Inactive Publication Date: 2011-02-16
HUAQIAO UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, this method is difficult to implement because the drug particles in the

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  • Method for preparing core-shell type composite microspheres by supercritical fluid technology
  • Method for preparing core-shell type composite microspheres by supercritical fluid technology
  • Method for preparing core-shell type composite microspheres by supercritical fluid technology

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Embodiment Construction

[0021] Nano-SiO with 5-fluorouracil (5-Fu) adsorbed on its surface 2 Disperse in 0.5% (wt / v) polylactic acid dichloromethane solution, ultrasonically disperse evenly and place in such as figure 1 Piston container front shown.

[0022] After the carbon dioxide in the steel cylinder is liquefied by the refrigeration system (condenser), it is pressurized by a high-pressure (plunger) pump, and then heated by a constant temperature water bath (heat exchanger) in the pipeline, and then pumped into the autoclave until the temperature in the autoclave reaches Maintain the required pressure, maintain the pumping rate of carbon dioxide, open the vent valve to release gas at a certain rate, and adjust the temperature of the external drying oven and pipeline water bath of the autoclave to keep the pressure and temperature inside the autoclave constant. After reaching the temperature required for the experiment, supercritical carbon dioxide passes through the outer channel of the coaxial ...

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Abstract

The invention discloses a method for preparing core-shell type composite microspheres by a supercritical fluid technology. The method comprises the following steps of: dissolving a polymer into an organic solvent which cannot be used for dissolving core material particles; dispersing the core material particles into the organic solvent of the polymer to obtain a suspension; then putting the suspension in a suspension conveying device; pumping in supercritical pure fluid through the suspension conveying device to form a solvent resistant effect to ensure that a polymer precipitate is separated out and coated on the surfaces of the core material particles so as to form core-shell type composite microspheres. The invention can improve the drug encapsulation rate and the slow releasing effect.

Description

technical field [0001] The invention relates to a novel method for preparing core-shell composite microspheres, in particular to a method for preparing core-shell composite microspheres by supercritical fluid technology. Background technique [0002] Supercritical carbon dioxide fluid is non-toxic, non-flammable, relatively cheap, high in solubility, recyclable, and low in critical point. The preparation of drug carriers by supercritical carbon dioxide fluid technology has mild reaction conditions, low temperature, simple process, and no or almost no solvent. Residue, small product particle size, controllable particle size distribution and other advantages, so supercritical carbon dioxide fluid technology has been widely used in the research of drug controlled release system. [0003] In the supercritical carbon dioxide rapid expansion method, the drug and polymer can be dissolved in supercritical carbon dioxide fluid, and then the drug and polymer are precipitated to form d...

Claims

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Application Information

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IPC IPC(8): A61J3/00
Inventor 陈爱政王士斌李翼
Owner HUAQIAO UNIVERSITY
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