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Iodine-contained effervescence composition and preparation method thereof

A composition and effervescent technology, applied in the directions of active ingredients of iodine compounds, drug combinations, pharmaceutical formulations, etc., can solve the problems of not using effervescent compositions, etc., and achieve the effect of broad market prospects

Inactive Publication Date: 2011-04-13
北京华素制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effervescent composition made of cediodine and other auxiliary materials in the prior art

Method used

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  • Iodine-contained effervescence composition and preparation method thereof
  • Iodine-contained effervescence composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] figure 1 It is a schematic flow diagram of the preparation method of the iodine-containing effervescent composition of the present invention. Such as figure 1 Shown, this preparation method comprises the following steps:

[0023] Step 10. Take 20%-45% of the acid source substance and 10%-28% of the filler and disintegrating agent or both of them by weight percentage, crush and sieve them and mix them evenly, then add 0.05% -2.5% binder granulated.

[0024] Step 20, taking 20% ​​to 45% of the carbon dioxide source material, 0.027% to 9.0% of cediodine and 2% to 12% of fillers and disintegrants in percentage by weight and crushing one or both of them respectively After sieving and mixing evenly, 0.05% to 2.5% of binder is added to granulate.

[0025] Step 30, after mixing the granules prepared in step 1 and step 2 with 3% to 15% by weight of one or more of sweeteners, flavoring agents, glidants and lubricants, The iodine-containing effervescent composition can be obt...

Embodiment 1

[0032] Embodiment 1: the raw material used for preparing iodine-containing effervescent composition is as follows:

[0033] cediiodine

27g

Mannitol

124g

tartaric acid

116g

sodium bicarbonate

132g

Hydroxypropylmethylcellulose

0.2g

polyethylene glycol 4000

9g

Sidi Brain

36g

[0034] sodium saccharin

3g

orange flavor

3g

Co-made

1000 pieces

[0035] Preparation:

[0036] First, weigh 84g of mannitol and 116g of tartaric acid, pulverize, sieve and mix uniformly, then add 8g of 1% hydroxypropyl methylcellulose solution to granulate, dry and granulate;

[0037] Next, weigh 40g of mannitol, 27g of cedi iodine and 132g of sodium bicarbonate, pulverize, sieve and mix uniformly, then add 12g of 1% hydroxypropyl methylcellulose solution to granulate, dry and granulate;

[0038] Finally, mix the above two kinds of granules with crushed and sieved 9g of ...

Embodiment 2

[0039] Embodiment 2: the raw material used for preparing iodine-containing effervescent composition is as follows:

[0040] cediiodine

27g

Mannitol

124g

tartaric acid

116g

sodium bicarbonate

132g

Low-substituted hydroxypropyl cellulose

4.5g

Hydroxypropylmethylcellulose

0.2g

polyethylene glycol 4000

9g

Sidi Brain

36g

sodium saccharin

3g

orange flavor

3g

Co-made

1000 pieces

[0041] Preparation:

[0042] First, weigh 84g of mannitol and 116g of tartaric acid, pulverize, sieve and mix uniformly, then add 8g of 1% hydroxypropyl methylcellulose solution to granulate, dry and granulate;

[0043] Next, take by weighing 40g of mannitol, 27g of cediline iodine and 132g of sodium bicarbonate are pulverized and sieved respectively and mixed uniformly, then add 12g of 1% hydroxypropyl methylcellulose solution to granulate, dry and granulate;

[0044]...

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Abstract

The invention relates to an iodine-contained effervescence composition and a preparation method thereof. The iodine-contained effervescence composition comprises the following components in percentage by weight: one or two 0.027-9.0 percent of cydiodine, 20-45 percent of acid source substance, 20-45 percent of carbon dioxide source substance, 0.1-5 percent of adhesive, 12-40 percent of filler and disintegrating agent and one or several 3-15 percent of sweetener, flavoring agent, glidant and lubricant. The iodine-contained effervescence composition prepared by the invention is used for rinsing the mouth after being effervescently dispersed and dissolved in water after a meal, removes food residues and dental plaque and freshens breath; meanwhile, due to the killing function on viruses and bacteria, the iodine-contained effervescence composition can be used for cleaning the oral cavity every day and assisting to treat chronic angina, dental ulcer, chronic gingivitis and periodontitis, thereby achieving multiple functions, filling the blank of the field and having wide market prospect.

Description

technical field [0001] The invention relates to an effervescent composition and a preparation method thereof, in particular to an iodine-containing effervescent composition and a preparation method thereof. Background technique [0002] Oral diseases such as oral ulcers, stomatitis, periodontitis, gingivitis, pericoronitis, etc., and throat diseases such as acute and chronic pharyngitis, tonsillitis are common and frequently-occurring diseases in the Department of Stomatology and Otorhinolaryngology. [0003] Mouthwash is a simple and easy method of oral health care, because it is impossible to brush teeth anytime and anywhere, but gargle is much simpler and can be done at any time. Gargling after a meal can wash away the food residue that has just adhered to the surface of the teeth and has not been fermented by bacteria, reducing the chance of dental disease. You should rinse your mouth in time. At the same time, gargling can also prevent bad breath and make the mouth cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/20A61K8/02A61K9/46A61K33/18A61Q11/00A61P1/02A61P11/04
Inventor 董国明石靖龙永鹏席红民
Owner 北京华素制药股份有限公司
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