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Medicine composition for treating ulcerative colitis and preparation method thereof
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A technology for ulcerative colitis and a composition, applied in the field of medicine, can solve problems such as ulcerative colitis that have not been reported, and achieve the effects of reducing the dosage of medicine, reducing the dosage of taking, and clearing the efficacy of the medicine
Inactive Publication Date: 2012-05-23
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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Abstract
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Problems solved by technology
[0003] At present, there is no report on the preparation of ulcerative colitis with Astragalus and Coptidis as raw materials
Method used
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Embodiment 1
[0025] The preparation of embodiment 1 pharmaceutical granule of the present invention
[0026] Take 450g each of Astragalus membranaceus and Coptis chinensis, decoct together, soak for 0.5h, decoct three times, each time for 0.5h, add 12 times, 10 times, and 8 times the amount of water respectively, combine the decoctions, concentrate to get a thick extract, add appropriate amount of dextrin 1. The soft material made of soluble starch is granulated through a 14-mesh sieve, and the obtained wet granules are dried at 60° C., and granulated through a 14-mesh sieve to obtain 1000 g of the finished product, which can be packed separately. Take it 3 times a day, each time is equivalent to 3.3g each of the crude drugs of Astragalus membranaceus and Coptis chinensis.
Embodiment 2
[0027] The preparation of embodiment 2 pharmaceutical tablet of the present invention
[0028] Take 500 g each of Radix Astragali and Coptidis Rhizome, prepare soft materials according to the method in Example 1, pass through a 20-mesh sieve to granulate, dry the obtained wet granules at 60°C, pass through a 20-mesh sieve for granulation, add appropriate amount of magnesium stearate, mix evenly, press Tablets, film-coated to get 1000 tablets. Take it 3 times a day, each taking is equivalent to 3.3g each of the crude drugs of Astragalus and Coptis chinensis.
Embodiment 3
[0029] The preparation of embodiment 3 pharmaceutical capsules of the present invention
[0030] Take 450g of Astragalus membranaceus and Coptis chinensis, take appropriate amount of Astragalus membranaceus and Coptis chinensis according to the method in Example 1 to prepare a thick extract, add appropriate amount of starch and dextrin, mix well, dry at 60°C, crush the obtained dry extract through a No. 6 sieve, add Appropriate amount of magnesium stearate is mixed evenly, and packed into 1000 capsules. Take it 3 times a day, each taking is equivalent to 3.3g each of the crude drugs of Astragalus and Coptis chinensis.
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Abstract
The invention provides a medicine composition for treating ulcerative colitis, which comprises the following Chinese medical herbs in parts by weight of 0.5-4 parts of astragalus root and 0.5-4 parts of goldthread. The invention also provides a preparation method and application of the medicine composition. The medicine composition is used for treating the ulcerative colitis, has remarkable medicine effect when in low dosage so as to reduce the medicine dosage, and is suitable for being used by patients; and the weight ratio of the astragalus root to the goldthread is preferably 1:1. In addition, effective components of the two Chinese medical herbs are defined, the medicine effect is more accurate through effective component compatibility, and the taking dosage is reduced, thus the invention provides a new selection for treating the ulcerative colitis clinically.
Description
technical field [0001] The invention relates to a pharmaceutical composition for treating ulcerative colitis and a preparation method thereof, belonging to the field of medicines. Background technique [0002] Ulcerative colitis (UC) is a non-infectious, unexplained inflammation that mainly invades the colonic mucosa and submucosa. Most of the onset is slow, and a few are acute onset. Occasionally, outbreaks occur (Chen Minzhang. Chinese Internal Medicine [ M]. Beijing: People's Health Publishing House, 1999: 2319.) Western medicine currently believes that the normal defense function of the intestinal mucosa is weakened, resulting in abnormal immune regulation, affecting the integrity of the intestinal mucosal barrier, making it difficult for the general intestinal mucosa to pass through the normal intestinal mucosa. Human harmless intestinal symbiotic flora, food and other antigens enter the intestinal mucosa, triggering a series of immune and inflammatory reactions (Qiu Zh...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P1/04A61P1/00
Inventor 李小芳王娇李珂
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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