Ceftezole sodium compound and novel method thereof

A technology of ceftezole sodium and ceftezole, which is applied in the medical field, can solve the problems affecting the efficacy of clinical medication and the purity of ceftezole sodium is not very high, and achieve the effects of low cost, reducing toxic and side effects, and ensuring safety

Inactive Publication Date: 2011-04-13
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purity of ceftezole sodium obtained by these two synthetic routes is not very high, which directly affects the curative effect of clinical medication, and further research and improvement are needed on its purity

Method used

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  • Ceftezole sodium compound and novel method thereof
  • Ceftezole sodium compound and novel method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The refining of embodiment 1 ceftezole sodium

[0028] (1) 100g ceftezole sodium crude product is dissolved in 1000ml water, then slowly add the hydrochloric acid of 0.1mol / L, the pH of stirring reaction to solution is 1.5, promptly produces ceftezole precipitation, suction filtration obtains ceftezole 83.9g;

[0029] (2) 83.9g of ceftezole obtained in the previous step is dissolved in 400g of methanol, adding activated carbon with a total solution volume of 4.0g, insulated at 60°C and stirred for 30min, filtered for decarburization, and the filtrate is collected;

[0030] (3) The filtrate obtained in step (2) is processed using an anion / cation exchange membrane electrodialysis device: the anion exchange membrane uses the AHA anion exchange membrane provided by Japan Tokuyama Soda Company, and the cation exchange membrane uses Japan Tokuyama Soda Company to provide CMB cation-exchange membrane, feeds the solution that obtains by step (2) in the concentrated chamber, inj...

Embodiment 2

[0036] The refining of embodiment 2 ceftezole sodium

[0037] (1) 100g ceftezole sodium crude product is dissolved in 1000ml water, then slowly add the phosphoric acid of 0.5mol / L, the pH of stirring reaction to solution is 1.8, promptly produces ceftezole precipitation, suction filtration obtains ceftezole 82.1g;

[0038] (2) 82.1g of ceftezole obtained in the previous step was dissolved in 350g of methylene chloride, 3.5g of gac was added, stirred at 60° C. for 20 minutes, filtered for decarburization, and the filtrate was collected;

[0039] (3) The filtrate obtained in step (2) is treated with an anion / cation exchange membrane electrodialysis device: the anion exchange membrane uses the NEOSEPTA ACS anion exchange membrane produced by ASTOM Corporation, and the cation exchange membrane uses the NEOSEPTA CMX cation exchange membrane produced by ASTOM Corporation membrane, feed the solution obtained in step (2) into the concentration chamber, inject purified water into the i...

Embodiment 3

[0045] The refining of embodiment 3 ceftezole sodium

[0046] (1) 100g ceftezole sodium crude product is dissolved in 1000ml water, then slowly add the phosphoric acid of 0.5mol / L, the pH of stirring reaction to solution is 2.5, promptly produces ceftezole precipitation, suction filtration obtains ceftezole 80.9g;

[0047] (2) Dissolve 80.9g of ceftezole obtained in the previous step in 300g of isopropanol, add 3.0g of activated carbon, insulate at 60°C and stir for 30min, filter for decarburization, and collect the filtrate;

[0048] (3) The filtrate obtained in step (2) is processed using an anion / cation exchange membrane electrodialysis device: the anion exchange membrane uses the AHA anion exchange membrane provided by Japan Tokuyama Soda Company, and the cation exchange membrane uses Japan Tokuyama Soda Company to provide CMB cation-exchange membrane, feed the solution that obtains by step (2) in the concentrating chamber, inject purified water in the impurity-removing cham...

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Abstract

The invention relates to a ceftezole sodium compound and a novel method thereof. The method provided by the invention achieves the refining aim by acidification reaction, activated carbon adsorption, electroosmosis device processing and preparation of chromatographic columns, so as to finally obtain a high-purity ceftezole sodium compound, overcomes the defects of low purity of the existing raw materials, improves the product quality of the preparation, reduces the toxic and side effects, and ensures the clinical safety of the medicine at the same time.

Description

technical field [0001] The invention relates to a ceftezole sodium compound and a new method thereof, belonging to the technical field of medicine. Background technique [0002] Ceftezole Sodium (Ceftezole Sodium), also known as Yi Tixin, the chemical name is 6R (trans)-8-oxo-7-[(1H-1-tetrazolylacetyl)amino]-3- [[2-(1,3,4-Thiadiazolyl)thio]methyl]-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid Sodium salt, the chemical formula is: C 13 h 11 N 8 NaO 4 S 3 , the structural formula is: [0003] [0004] Ceftezole sodium is a semi-synthetic cephalosporin antibiotic synthesized and developed by Japan Fujisawa Co., Ltd., which was launched in April 1978 under the trade name of Ceolslin. The application of ceftezole sodium in my country is relatively late. In 2002, Harbin Pharmaceutical and Tianjin Xinfeng had the production of raw materials and preparations. [0005] Ceftezole Sodium is mainly used to treat infections caused by Staphylococcus aureus, Streptococcu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/36C07D501/12
Inventor 胡建荣
Owner HAINAN LINGKANG PHARMA CO LTD
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