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Lincomycin and spectinomycin compound oil suspension injection and preparation method and application thereof

A technology of suspension injection and spectinomycin, which is applied in the fields of pharmaceutical formulation, emulsion delivery, and medical preparations containing active ingredients, etc., can solve the problems of difficult stability of compound injection and large irritation of animal organisms, and achieve Overcoming the effect of low bioavailability, great promotion value and improving stability

Active Publication Date: 2011-05-11
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the stability of lincomycin and spectinomycin compound injection is a difficult problem for many manufacturers.
And because the pH value of the spectinomycin solution drops rapidly, the intramuscular injection is more irritating to the animal body

Method used

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  • Lincomycin and spectinomycin compound oil suspension injection and preparation method and application thereof
  • Lincomycin and spectinomycin compound oil suspension injection and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Prepare each component according to the following formula

[0026] Lincomycin hydrochloride 5g (converted into pure drug, the same below);

[0027] Spectinomycin hydrochloride 10g (converted into pure medicine, the same below);

[0028] Aluminum monostearate 2g;

[0029] Span-80 0.15g;

[0030] Soy lecithin 0.05g;

[0031] Propyl gallate 0.01g;

[0032] Soybean oil for injection 100mL.

[0033] Preparation

[0034] (1) Put 70mL of soybean oil for injection into an autoclave to sterilize at 150°C for 2 hours;

[0035] (2) Take out the sterilized soybean oil for injection obtained in step (1), add the suspending agent aluminum monostearate after it is cooled to about 60°C, and then continue to place it in the autoclaving cabinet to heat at 120°C and stir for 1 hour After ~2 hours, it can be taken out after it becomes a transparent gel solution system;

[0036] (3) Add emulsifier soy lecithin to the gel solvent system obtained in step (2) at about ...

Embodiment 2

[0038] Embodiment 2 Prepare each component according to the following formula

[0039] Lincomycin Hydrochloride 5g;

[0040] Spectinomycin Hydrochloride 10g;

[0041] Hydrogenated castor oil 0.5g;

[0042] Span-80 0.5g;

[0043] Soy lecithin 0.2g;

[0044] Propyl gallate 0.01g;

[0045] Soybean oil for injection 100mL.

[0046] Preparation

[0047] (1) Put 70mL of soybean oil for injection into an autoclave to sterilize at 150°C for 2 hours;

[0048] (2) Take out the sterilized soybean oil for injection obtained in step (1), and add suspending agent hydrogenated castor oil when it is cooled to about 60°C, then continue to heat and stir until it becomes a transparent gel and dissolves;

[0049] (3) Add emulsifier soybean lecithin to the gel solvent system obtained in step (2) at about 100°C, add wetting agent Span-80 and antioxidant propyl gallate after cooling to about 30°C, and stir to prepare Mixed excipient gel solvent system;

[0050] (4) Add lincomycin hydrochlo...

Embodiment 3

[0051] Embodiment 3 Prepare each component according to the following formula

[0052] Lincomycin Hydrochloride 5g;

[0053] Spectinomycin Hydrochloride 10g;

[0054] Aluminum monostearate 1g;

[0055] Span-80 0.4g;

[0056] Soy lecithin 0.15g;

[0057] Vitamin E 0.01g;

[0058] Soybean oil for injection 100mL.

[0059] Preparation

[0060] (1) Put 70mL of soybean oil for injection into an autoclave to sterilize at 150°C for 2 hours;

[0061] (2) Take out the sterilized soybean oil for injection obtained in step (1), add the suspending agent aluminum monostearate after it is cooled to about 60°C, and then continue to place it in the autoclaving cabinet to heat at 120°C and stir for 1 hour After ~2 hours, it can be taken out after it becomes a transparent gel solution system;

[0062] (3) Add emulsifier soybean lecithin to the gel solvent system obtained in step (2) at about 100°C, add wetting agent Span-80 and antioxidant vitamin E after cooling to about 30°C, and s...

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PUM

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Abstract

The invention discloses a lincomycin and spectinomycin compound oil suspension injection and a preparation method and application thereof. The injection comprises a mixed auxiliary material solvent, lincomycin hydrochloride and spectinomycin hydrochloride. The mixed auxiliary material solvent system comprises oil or ester for injection, suspending agent, emulsifier, wetting agent and antioxidant. The preparation method comprises adding suspending agent into oil or ester for injection to obtain gel solvent system, sequentially adding emulsifier, wetting agent and antioxidant, adding lincomycin hydrochloride and spectinomycin hydrochloride, and grinding with a colloidal mill. The invention can effectively improve the stability of spectinomycin and reduce the irritation on animal body during usage, and has simple preparation process, strong operability and high value of popularization.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotics, and in particular relates to a compound oil suspension injection of lincomycin and spectinomycin and its preparation method and application. Background technique [0002] Lincomycin (lincomycin) is a lincosamide antibiotic, which has a strong antibacterial effect on most anaerobic bacteria and Gram-positive bacteria. Spectinomycin is an aminoglycoside antibiotic that has antibacterial effects on Gram-negative bacteria, positive bacteria and mycoplasma. The combination of lincomycin and spectinomycin, also known as riscomycin, has a synergistic effect, a broad antibacterial spectrum, rapid action, low toxicity, and no adverse effects on chickens and pigs. It has a good curative effect on piglet diarrhea, pig mycoplasma pneumonia and chicken chronic respiratory disease caused by Mycoplasma gallisepticum. [0003] The existing compound formulations of lincomycin and spectinomycin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/357A61K9/00A61K9/107A61P31/04A61P1/12A61P11/00
Inventor 曾振灵王忠王立琦黄显会贺利民丁焕中
Owner SOUTH CHINA AGRI UNIV
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