Composition for preventing or treating apoplexy and application thereof

Abstract

The invention relates to a composition for preventing or treating apoplexy and a preparation method thereof, wherein the composition comprises the following components in parts by weight: 4.8-10 parts of notoginsenoside R1, 19.8-45 parts of ginsenoside Rg1, 20-40 parts of ginsenoside Rb1, 3.5-6 parts of ginsenoside Re and 1.5-9.9 parts of ginsenoside Rd. The composition provided by the invention has the advantages of obvious effect and high safety and can obviously shorten the course of the disease and relieve the pain.

Description

technical field

[0001] The invention relates to the field of medicines, in particular to a composition for preventing or treating apoplexy. Background technique

[0002] Cerebral stroke is a group of diseases whose main clinical manifestations are cerebral ischemia and hemorrhagic injury symptoms, also known as stroke or cerebrovascular accident. The onset of stroke is acute and has a very high mortality rate and disability rate. According to the report of the World Health Organization, the death rate due to stroke ranks second in the global mortality rate, second only to cancer, and about 1 / 2 of the annual death toll 4 out of 10 people die from strokes. There are more than 10 types of cancer. If the mortality rate of a single type is considered, stroke can be ranked first in the mortality rate. In the United States, the mortality rate of first-time stroke patients is about 7%, and the mortality rate in my country is even higher. Cerebral stroke is still the primary cause...

Examples

Embodiment 1

[0049] Extraction of components:

[0050] Grind 1000 g of Panax notoginseng medicinal material into coarse powder, add 2.5 times the amount of 90% ethanol, heat and reflux for extraction, and concentrate under reduced pressure until there is no alcohol smell. Add water to dilute to 0.3g (crude drug) / ml, let stand for 24 hours, and filter. The filtrate was passed through a macroporous adsorption resin column, and was sequentially eluted with 20%, 40%, 60%, 80% and 95% (volume ratio) ethanol gradient, with a flow rate of 8ml / min and collected in 500ml portions. The eluate was analyzed by silica gel H thin-layer chromatography, the developer was "n-butanol-ethyl acetate-water" 5:0.5:4 (upper layer), and 10% (volume ratio) sulfuric acid ethanol solution was used for color development. The same components of the chromatographic spots were combined, and the solvent was recovered under reduced pressure. Then apply the chromatography to the silica gel column and elute with the solve...

Embodiment 2

[0060] Weigh the following components by weight: notoginsenoside R1 4.8g, ginsenoside Rg1 19.8g, ginsenoside Rb 120g, ginsenoside Re 3.5g, ginsenoside Rd 1.5g.

[0061] The preparation method is as follows: mix the above-mentioned components, dissolve in an appropriate amount of water for injection, decolorize with activated carbon for injection, filter, add water for injection to the total amount, adjust the pH value to 6.0, filter, and freeze-dry to obtain the product.

Embodiment 3

[0063] Weigh the following components by weight: notoginsenoside R1 10g, ginsenoside Rg1 45g, ginsenoside Rb1 40g, ginsenoside Re 6g, ginsenoside Rd 9.9g.

[0064] The preparation method is as follows: mix the above-mentioned components, dissolve in an appropriate amount of water for injection, decolorize the injection with activated carbon, filter, add water for injection to the total amount, adjust the pH value to 7.0, filter, and freeze-dry to obtain the product.

technical field

[0001] The invention relates to the field of medicines, in particular to a composition for preventing or treating apoplexy. Background technique

[0002] Cerebral stroke is a group of diseases whose main clinical manifestations are cerebral ischemia and hemorrhagic injury symptoms, also known as stroke or cerebrovascular accident. The onset of stroke is acute and has a very high mortality rate and disability rate. According to the report of the World Health Organization, the death rate due to stroke ranks second in the global mortality rate, second only to cancer, and about 1 / 2 of the annual death toll 4 out of 10 people die from strokes. There are more than 10 types of cancer. If the mortality rate of a single type is considered, stroke can be ranked first in the mortality rate. In the United States, the mortality rate of first-time stroke patients is about 7%, and the mortality rate in my country is even higher. Cerebral stroke is still the primary cause...

Examples

Embodiment 1

[0049] Extraction of components:

[0050] Grind 1000 g of Panax notoginseng medicinal material into coarse powder, add 2.5 times the amount of 90% ethanol, heat and reflux for extraction, and concentrate under reduced pressure until there is no alcohol smell. Add water to dilute to 0.3g (crude drug) / ml, let stand for 24 hours, and filter. The filtrate was passed through a macroporous adsorption resin column, and was sequentially eluted with 20%, 40%, 60%, 80% and 95% (volume ratio) ethanol gradient, with a flow rate of 8ml / min and collected in 500ml portions. The eluate was analyzed by silica gel H thin-layer chromatography, the developer was "n-butanol-ethyl acetate-water" 5:0.5:4 (upper layer), and 10% (volume ratio) sulfuric acid ethanol solution was used for color development. The same components of the chromatographic spots were combined, and the solvent was recovered under reduced pressure. Then apply the chromatography to the silica gel column and elute with the solve...

Embodiment 2

[0060] Weigh the following components by weight: notoginsenoside R1 4.8g, ginsenoside Rg1 19.8g, ginsenoside Rb 120g, ginsenoside Re 3.5g, ginsenoside Rd 1.5g.

[0061] The preparation method is as follows: mix the above-mentioned components, dissolve in an appropriate amount of water for injection, decolorize with activated carbon for injection, filter, add water for injection to the total amount, adjust the pH value to 6.0, filter, and freeze-dry to obtain the product.

Embodiment 3

[0063] Weigh the following components by weight: notoginsenoside R1 10g, ginsenoside Rg1 45g, ginsenoside Rb1 40g, ginsenoside Re 6g, ginsenoside Rd 9.9g.

[0064] The preparation method is as follows: mix the above-mentioned components, dissolve in an appropriate amount of water for injection, decolorize the injection with activated carbon, filter, add water for injection to the total amount, adjust the pH value to 7.0, filter, and freeze-dry to obtain the product.