New technology for extracting Chinese magnoliavine fruit lignanoid

Abstract

The invention belongs to the technical field of medicines, and relates to the new technology for extracting Chinese magnoliavine fruit lignanoid. A preparation process comprises the following steps of: crushing Chinese magnoliavine fruit, adding 60 to 100 percent of methanol or ethanol and 0.5 to 5 percent of surfactant, performing reflux extracting for 1 to 2 times, and mixing extract, wherein the reflux extracting is performed for 1 to 2 hours every time; concentrating the extract under reduced pressure, removing the methanol or the ethanol, adding ester organic solvent for extracting; and concentrating an extract phase to recover the ester organic solvent, dissolving in proper amount of water, and purifying by adopting adsorbent resin, and eluting by 30 to 90 percent of ethanol to obtain the Chinese magnoliavine fruit lignanoid with 70 to 98 percent of lignanoid. The new technology has the characteristics that: after the surfactant is added, the extraction efficiency can be improved by over 30 percent, the extracting time can be reduced, clarified solution can be obtained, and an upper absorption column is not blocked due to ester insoluble substances; and by adding the ester organic solvent, pigment impurities can be removed effectively, the competitive adsorption of pigment on the absorption column can be reduced, and the purity of final products can be improved.

Description

technical field [0001] The invention relates to a method for extracting and purifying schisandra lignans, which belongs to the technical field of medicine, and in particular uses methanol or ethanol aqueous solution containing surfactants for extraction, and ester organic solvents for extraction and decolorization. Background technique [0002] Schisandra chinensis (Schisandra chinensis (Turcz.) Baill) is the dry and mature fruit of Magnolia plant Schisandra chinensis (Turcz.) Baill. It has a long history as a tonic and strengthening agent in traditional Chinese medicine. It is proved that schisandra can reduce transaminase and improve symptoms of viral hepatitis or chemical poisoning liver injury, excite the central nervous system, improve the formation of conditioned reflex, and improve the function of cerebral cortex cells. [0003] At present, the extraction methods of schisandra lignans mainly include carbon dioxide supercritical fluid extraction and organic solvent ext...

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a method for extracting and purifying schisandra lignans, using methanol or ethanol aqueous solution containing surfactants to extract, obtain a uniform and clear solution, and solve the problem that lipid insoluble substances in the extract cannot be extracted due to precipitation. The waste caused by resin adsorption and the blockage of the adsorption column can be improved by adding surfactants to the extraction rate of more than 30%, and the number of extractions can be reduced; the addition of ester organic solvents can effectively remove pigment impurities and reduce the impact of pigment on the adsorption column. Competitive adsorption to improve the purity of the final product