Process for making gastroretentive dosage forms

A technology for gastric retention and dosage forms, applied in pharmaceutical formulations, pill delivery, drug delivery, etc., can solve problems such as inability to provide load rate, inapplicable active ingredients, and difficulty in implementation

Inactive Publication Date: 2014-12-31
地中海大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the above technical solutions are not suitable for any type of active ingredients, cannot provide arbitrary loading rates, and are difficult to implement

Method used

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  • Process for making gastroretentive dosage forms
  • Process for making gastroretentive dosage forms
  • Process for making gastroretentive dosage forms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0119] Preparation of solid dosage form according to the invention

[0120] Two different solid dosage forms (100 g batches) of the following compositions were prepared according to the present invention. Dosage form No. 1 includes hydrophilic API, and dosage form No. 2 includes hydrophobic API. The enlarged pictures of the structure No. 1 and No. 2 dosage forms are in image 3 Given in.

[0121]

[0122]

77.5％

[0123] The API powder and other auxiliary materials are loaded in a shear mixer 4M8 granulator and mixed for 2 minutes and 30 seconds at 150 rpm. The granulation was initiated by adding water at a rate of 10 ml / min at 1000 rpm. Over granulation was reached after introducing 80 ml of water to form a solution: powder ratio of 0.8, and the resulting paste was further kneaded at 1500 rpm for 2 minutes and 30 seconds until it showed 4 to 8% torque resistance. The resulting material is then molded in a paraffin oil lubricated shell. The last drying step carried out was...

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PUM

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Abstract

The present invention relates to a novel process for making oral solid gastro-retentive forms, comprising the steps of providing a powder mixture comprising a hydrophobic powder, overgranulating this powder mixture with a granulating solution into an overgranulated paste, and drying said paste into a solid, as well as to pharmaceutical solid dosage forms which are retained in the stomach or upper gastrointestinal tract for a controlled delivery of a drug.

Description

Technical field [0001] The present invention relates to a new pharmaceutical composition that is retained in the stomach or upper digestive tract to achieve controlled drug delivery. The present invention also provides methods for preparing these dosage forms and methods for using these dosage forms in therapy. Background technique [0002] The efficiency of therapeutic agents is closely related to their method of administration. When taken orally, the drug interacts with specific absorption sites located in different parts of the gastrointestinal tract (GI), causing certain agents to be absorbed only in the stomach, upper or lower intestinal tract. Therefore, because these drugs are not uniformly absorbed throughout the length of the gastrointestinal tract, the absorption rate is not constant, and the most effective treatment cannot be performed. These may be significantly improved when the method of administration provides controlled delivery of the active ingredient to the r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20
CPCA61K9/0065
Inventor 帕斯卡尔·普兰德尔克里斯托夫·索泽
Owner 地中海大学
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