Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases

An envelope protein, virus envelope technology, applied in antiviral immunoglobulins, antiviral agents, fusion polypeptides, etc., can solve the problems of virus mutagenic adaptive antiviral strategies, drug resistance, loss of efficacy and other problems

Inactive Publication Date: 2011-06-29
ABLYNX NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0017] However, currently existing antiviral drugs have many side effects such as nausea, vomiting, rashes, migraines, weakness, tremors, and less rarely, seizures
[0018] In addition, the mutability of viruses and the consequent adaptability pose great difficulties in designing long-term effective antiviral strategies
Although drug design has benefited from advances in the molecular understanding of the viral growth process, many initially effective drugs lose their efficacy over time as resistant strains emerge

Method used

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  • Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases
  • Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases
  • Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases

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Embodiment Construction

[0871] In the description, examples and claims:

[0872] a) Unless otherwise specified or defined, all terms used have their ordinary meanings in the art, which should be clear to a skilled person. For example, refer to the standard manual on page 46, paragraph a) of WO 08 / 020079;

[0873] b) unless otherwise indicated, the terms "immunoglobulin sequence", "sequence", "nucleotide sequence" and "nucleic acid" are as described on page 46, paragraph b) of WO 08 / 020079;

[0874] c) Unless otherwise indicated, all methods, steps, techniques and manipulations not specifically described in detail can and have been performed in a manner known per se, as will be clear to the skilled artisan. For example, still refer to standard handbooks, refer to the known background art mentioned in the present invention, and refer to other references cited therein; and refer to for example the following review Presta, Adv.Drug Deliv.Rev. (Advanced Drug Delivery Review) 2006 , 58(5-6): 640-56; Levi...

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Abstract

The present invention relates in part to amino acid sequences that are directed against and / or that can specifically bind to an envelope protein of a virus, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.

Description

field of invention [0001] The present invention relates to viral envelope proteins and / or amino acid sequences that can specifically bind to viral envelope proteins, as well as amino acid sequences comprising one or more of said amino acid sequences or consisting essentially of one or more of said amino acid sequences Compounds or constructs, and especially proteins and polypeptides (also referred to herein as "amino acid sequences of the invention", "compounds of the invention", and "polypeptides of the invention", respectively). [0002] The present invention also relates to nucleic acids encoding said amino acid sequences and polypeptides (also referred to herein as "nucleic acids of the invention" or "nucleotide sequences of the invention"); methods of preparing said amino acid sequences and polypeptides; expressing or capable of A host cell expressing said amino acid sequence or polypeptide; a composition comprising said amino acid sequence, polypeptide, nucleic acid and / ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395C07K16/08
CPCC07K16/1018C07K2317/569C07K16/1009C07K16/1027A61K2039/507C07K2319/00C07K2317/565C07K2317/92A61K2039/505C07K2317/24C07K16/10C07K2316/96C07K2317/22C07K2317/55C07K2317/76C07K2317/64A61P31/14C07K2317/31C07K2317/622C07K2317/35C07K2317/53C07K2317/567C07K2317/94
Inventor 安娜·赫尔特伯格布拉姆·马森彼得·万兰德舒特埃里克·德普拉卡特林恩·斯托特勒斯科内利斯·特奥多鲁斯·韦里普斯史蒂文·范古特何塞·梅莱罗迈克尔·约翰·斯科特·桑德斯约翰内斯·约瑟夫·威廉姆斯·德哈德罗伯特·安东尼·韦斯奈杰尔·詹姆斯·坦珀顿泽维尔·塞伦伯特·舍潘亚历山大·希罗基迈克尔·马里·哈姆森
Owner ABLYNX NV
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