Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof

A technology for reperfusion injury and myocardial ischemia, which can be used in drug combination, drug delivery, pharmaceutical formulations, etc., and can solve problems such as rare compound research.

Inactive Publication Date: 2011-07-06
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the prevention and treatment of myocardial ischemia in traditional Chinese medicine is mostly focused on the research of traditional Chinese medicine monomers, and there are few studies on compound prescriptions. There are no drugs that affect the main subtype genes and proteins of the ATP-sensitive K channel in ischemic cardiomyocytes.

Method used

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  • Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 (preparation mixture)

[0028] Weigh the 7-day amount of the above medicinal materials in proportion, add 10 times the amount of water and 8 times the amount respectively, decoct twice, combine the filtrate, and concentrate the filtrate to 5 grams of crude drug per milliliter; add 3 times the amount of ethanol to the concentrated solution, and the alcohol content reaches About 60%, refrigerated for 24 hours, filtered, the filtrate recovered ethanol until it had no alcohol smell; the recovered solution was boiled, added 3 grams of sodium benzoate, 0.25 grams of ethyl paraben (dissolved in water), filtered and allowed to cool, Add water to 500ml and fill while hot.

Embodiment 2

[0029] Embodiment 2 (preparation mixture)

[0030] Weigh the 7-day amount of Scallion Radix in proportion, crush it to 10-40 mesh, and extract the volatile oil by steam distillation or supercritical extraction method for later use; in addition, weigh the 7-day amount of Salvia miltiorrhiza in proportion, extract it with 75% ethanol, and extract it by reflux method. Recover ethanol for later use; add 5-10 times the amount of water to the residues of Allium and Salvia miltiorrhiza and the rest of the raw materials weighed in proportion, decoct two to three times, combine the filtrate, and concentrate the filtrate to 5 grams of crude drug per milliliter; use flocculation and precipitation method , stand still for 24 hours, centrifuge and filter with a centrifugation speed of 5000 rpm, add scallion volatile oil and salvia miltiorrhiza ethanol extract to the filtrate, mix well, add 3 grams of sodium benzoate, 0.25 grams of ethyl paraben (dissolved in water), Filter and let cool, ad...

Embodiment 3

[0031] Embodiment 3 (preparation of granules)

[0032] Weigh the 7-day amount of crude drug in proportion, add 10 times and 8 times of water respectively, decoct twice, combine the filtrate, and concentrate the filtrate to 5 grams of crude drug per milliliter; add 3 times the amount of ethanol to the concentrated solution, and the alcohol content reaches About 60%, refrigerated for 24 hours, filtered, recovered ethanol from the filtrate until it has no alcohol smell, concentrated the recovered liquid to a relative density of 1.25-1.30 (room temperature), added an appropriate amount of dextrin or starch, wet granulated, dried, and made Granules 500 grams, ready to pack.

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury. The traditional Chinese medicine composition is a medicament prepared by the following active pharmaceutical ingredients in portions by weight: 15-30 portions of membranous milkvetch root, 12-30 portions of motherwort herb, 6-15 portions of longstamen onion bulb, 12-30 portions of hawthorn fruit, 20-45 portions of whole trichosanthes, 9-18 portions of radix salviae miltiorrhizae, 9-18 portions of prepared pinellia tuber and 9-18 portions of kudzuvine root. In addition, the invention further relates to a preparation method for the traditional Chinese medicine composition.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating myocardial ischemia-reperfusion injury; the invention also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Coronary heart disease is the main killer of human health. With the acceleration of globalization, cardiovascular and cerebrovascular diseases have begun to spread in developing countries and become the number one cause of death in the world. Coronary heart disease can also be called ischemic heart disease, which can cause clinically a series of severe myocardial ischemia diseases such as angina pectoris and myocardial infarction. A large number of studies have shown that myocardial ischemia has a great relationship with the opening of ATP-sensitive potassium channels in cardiomyocytes. As a "natural therapy", traditional Chinese medicine has the advantages of low price and less toxic and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/08A61K9/16A61P9/10
Inventor 刘萍章怡祎张娜韩向晖史秀峰蔡珏峰陈富荣
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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