Method for quickly detecting drug

Abstract

The invention discloses a method for quickly detecting a drug. The method comprises the following steps of: (1) pretreating a sample; (2) performing gas chromatography separation and mass spectrum scan analysis on the sample; (3) performing extract ion analysis on each chromatographic peak on a total ion chromatogram by using a mass spectrum characteristic ion of a common drug and initially judging a suspected drug component; (4) drawing an extract multi-ions figure of the chromatographic peaks by using the characteristic ion of the suspected drug component, calculating the abundance ratio of the characteristic ion and determining whether the drug component exists in the sample or not; and (5) performing gas chromatography-mass spectrum analysis on a standard substance of the suspected drug component and measuring the content of the drug by adopting an external standard method. By adopting the method, a qualitative result is reliable and a quantitative result is correct. Meanwhile, a plurality of drugs can be detected at the same time, so that the efficiency is greatly improved and the detection cost is lowered.

Description

Technical field [0001] The invention relates to the technical field of drug detection, in particular to a method for rapid drug detection, which can be used for rapid qualitative and quantitative detection of drugs in drugs and drug addicts' body fluids. Background technique [0002] The reliability of drug detection methods is the key to the accuracy of the test results. At present, my country's testing standards are relatively backward, which has attracted great attention from the government. [0003] There is no national standard method for drug testing. There are only ministerial standard methods issued by the Ministry of Public Security, most of which were formulated in the 1990s. Most of these analytical methods are gas chromatography, thin-layer chromatography, and ultraviolet spectrophotometry. A few use high-performance liquid chromatography. The technical means are relatively backward, especially the serious lack of qualitative confirmation information, which interferes ...

AI Technical Summary

Problems solved by technology

First use the method of enzyme-linked immunoimmunoassay kit (or test strip) for screening. The advantages of this method are that it is fast, simple and low in cost. However, this method is not reliable and can easily lead to false positive results. sieve, positive results need to be confirmed by chromatography

However, as mentioned above, the chromatographic method only relies on retention time for qualitative determination, and the problem of false positives has already appeared. Therefore, a simple, fast, accurate and reliable detection method that can detect multiple drugs at the same time is urgently needed to solve the current problem of drug detection.

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