MRI-CEST diagnostic technique based on non-punctual analysis

A technology of MRI-CEST and diagnostic system, applied in the direction of magnetic resonance measurement, measuring devices, instruments, etc., can solve problems such as limiting the accuracy of MRI-CEST technology and missing target areas

Active Publication Date: 2011-07-20
BRACCO IMAGINIG SPA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All of the above factors limit the accuracy of MRI-CEST technology (possible misdetection

Method used

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  • MRI-CEST diagnostic technique based on non-punctual analysis
  • MRI-CEST diagnostic technique based on non-punctual analysis
  • MRI-CEST diagnostic technique based on non-punctual analysis

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Embodiment Construction

[0040] refer to figure 1 , shows an MRI scanner to which the scheme according to one embodiment of the invention is applicable. The scanner 100 includes a table 105 on which a patient 110 lies for analysis. The platform 105 can slide inside the tunnel 115 . The tunnel 115 houses a permanent magnet 120 that generates a very high static magnetic field Bo (eg, on the order of 1-9T). Multiple sets of gradient coils 125 (typically three sets of gradient coils 125, each for a different direction) are coupled to the magnet 120 for adjusting the magnetic field Bo. The tunnel 115 also houses a radio frequency (RF) coil 130, which applies a magnetic pulse B1 to a particular body part of the patient 110 to be analyzed and receives an RF magnetic response signal returned by the same body part; 110 is designed for the type of body part (eg, shoulder, knee, spine, head, etc.) with different configurations (eg, surface coil, saddle coil, Helmholtz coil, etc.). Tunnel 115 has magnetic shi...

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PUM

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Abstract

A solution in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system (100) includes input means (505-550) for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means (555,563) for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated in a non-punctual agent range of frequencies including the agent frequency e.g. by integrating the spectrum, and the reference value is calculated in a non-punctual reference range of frequencies including the reference frequency e.g. by integrating the spectrum. Comparison means (565) is then provided for calculating a parametric value for each selected location by comparison between the agent value and the reference value of the selected location.

Description

technical field [0001] The solution according to one or more embodiments of the present invention relates to the field of medical devices. More specifically, the approach relates to the field of magnetic resonance imaging (MRI) of the chemical exchange saturation transfer (CEST) type. Background technique [0002] MRI is a well-established technique (in the field of medically applied devices) that allows analysis of body parts of a patient in an essentially non-invasive manner. In general, MRI is based on the application of high magnetic fields to parts of the body. By measuring the magnetic response of a body part as it reacts differently to the magnetic field depending on its properties, it is possible to derive morphological and / or physiological information about the body part (eg for display of corresponding images). [0003] For this purpose, in standard MRI techniques magnetic pulses are applied to the body part in order to change its magnetization. The magnetizatio...

Claims

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Application Information

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IPC IPC(8): G01R33/28
CPCG01R33/5601G01R33/5608
Inventor S·艾米D·德里·卡斯特利D·L·朗格J·斯坦卡内罗E·特雷诺F·乌格里
Owner BRACCO IMAGINIG SPA
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