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Method for preparing Herperione, application thereof, capsule thereof, preparation method and application of capsule

A technology of silica gel column and petroleum ether, which is applied in the field of preparation of Herpetrione, can solve problems affecting drug dissolution and absorption, poor control of drug quality, separate active ingredients, etc., to achieve stable extraction and preparation process, small drug dosage, and prescription volume The effect of small dosage

Active Publication Date: 2013-04-10
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because its active ingredients are insoluble lignans, it greatly affects the dissolution and absorption of drugs.
In the patent publication document of CN1857367, the inventor disclosed that the extract of the melon seeds containing PED I, PED II, herpetal, herpetin, herpetrione and herpetetrone was extracted from the melon seeds, but due to the limitation of the extraction process, the effective The ingredients are separated separately, so the quality of medication is not well controlled and the pertinence is not strong when treating hepatitis B.

Method used

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  • Method for preparing Herperione, application thereof, capsule thereof, preparation method and application of capsule
  • Method for preparing Herperione, application thereof, capsule thereof, preparation method and application of capsule
  • Method for preparing Herperione, application thereof, capsule thereof, preparation method and application of capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment one: Preparation of Herpetrione:

Embodiment 1-1

[0035] The preparation of embodiment 1-1, Herpetrione:

[0036] (1) After pulverizing the dried product of Boling melon seeds, the coarse powder of Boling melon seeds is obtained. The coarse powder is defined as coarse powder according to the Pharmacopoeia of the People's Republic of China (Part One, 2005 Edition), which means that all of them pass through the standard No. 2 sieve. But mixed with powder that can pass through standard No. 4 sieve not more than 40%. ;

[0037] (2), decocting and extracting the wave-lens melon seed meal with 80% ethanol of 6 to 10 times the amount of the meal, extracting twice, each time for 2 hours, and merging to obtain the decoction;

[0038] (3), the decoction liquid that step (1) obtains adopts the plate-and-frame suction filtration method to carry out suction filtration, and filtrate is concentrated under reduced pressure at 60 ℃ to 2g crude drug / ml, let cool, high-speed centrifugation, separates oil layer and water layer, Add petroleum e...

Embodiment 1-2

[0040] The preparation of embodiment 1-2, Herpetrione:

[0041]The steps of this example are the same as those of Example 1-1, except that the amount of ethanol added in step (2) is 8 times the amount of coarse powder; the amount of 10% ethanol added in step (3) is 1 / 16 of the amount of crude drug.

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Abstract

The invention relates to a method for preparing Herperione, application and capsules of Herperione, a preparation method and application of capsules, belonging to the technical field of Chinese herbal preparation. The method for preparing Herperione comprises the following steps: (1) carrying out alcohol extraction on herpetospermum caudigerum coarse powder so as to obtain a decoction liquid; (2)carrying out pumping filtration and concentration on the decoction liquid so as to remove fatty oil till petroleum ether is colorless; volatilizing the decoction liquid at the normal temperature tillthe decoction liquid does not have petroleum ether smell; adding 10% of ethanol solution for scrubbing, taking ethyl acetate for sedimentation so as to repeatedly dissolve; recycling and drying ethylacetate so as to obtain crude products; (3) applying silica gel to the crude products for preparation in middle pressure, and collecting, recycling and drying fractions so as to obtain the Herperione. Probe ultrasound and high pressure homogenization are carried out on the Herperione so as to obtain a mixed suspension liquid which is dried, palletized and encapsulated so as to obtain capsules of Herperione. The Herperione and the capsules of Herperione are used for treating hepatitis B. The invention has the advantages of stable extraction and preparation process, controllable quality, small dosage of prescription, good curative effect, fast drug release, easy absorption by oral administration and the like.

Description

technical field [0001] The invention belongs to the technical field of inventions of traditional Chinese medicine preparations, and in particular relates to a method for preparing Herpetrione and an application thereof, a capsule thereof, and a preparation method and application of the capsule. Background technique [0002] my country is a high-incidence area of ​​viral hepatitis, among which chronic hepatitis B has attracted special attention because of its gradual development, difficulty in control, poor prognosis and complicated pathogenesis. At present, nearly 130 million people in the country are carriers of hepatitis B virus, 50 million people suffer from chronic hepatitis, and about 230,000 people die of hepatitis every year (a survey statistics from the Ministry of Health in December 2002 showed that: hepatitis It is still the infectious disease with the highest morbidity and mortality in my country), plus other known and unknown viral hepatitis diseases caused by vir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A61K31/34A61K9/48A61P31/20
Inventor 袁海龙郭静静李仙义韩晋吕俊兰付珊珊
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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