Method for preparing Herperione, application thereof, capsule thereof, preparation method and application of capsule

Abstract

The invention relates to a method for preparing Herperione, application and capsules of Herperione, a preparation method and application of capsules, belonging to the technical field of Chinese herbal preparation. The method for preparing Herperione comprises the following steps: (1) carrying out alcohol extraction on herpetospermum caudigerum coarse powder so as to obtain a decoction liquid; (2)carrying out pumping filtration and concentration on the decoction liquid so as to remove fatty oil till petroleum ether is colorless; volatilizing the decoction liquid at the normal temperature tillthe decoction liquid does not have petroleum ether smell; adding 10% of ethanol solution for scrubbing, taking ethyl acetate for sedimentation so as to repeatedly dissolve; recycling and drying ethylacetate so as to obtain crude products; (3) applying silica gel to the crude products for preparation in middle pressure, and collecting, recycling and drying fractions so as to obtain the Herperione. Probe ultrasound and high pressure homogenization are carried out on the Herperione so as to obtain a mixed suspension liquid which is dried, palletized and encapsulated so as to obtain capsules of Herperione. The Herperione and the capsules of Herperione are used for treating hepatitis B. The invention has the advantages of stable extraction and preparation process, controllable quality, small dosage of prescription, good curative effect, fast drug release, easy absorption by oral administration and the like.

Description

technical field [0001] The invention belongs to the technical field of inventions of traditional Chinese medicine preparations, and in particular relates to a method for preparing Herpetrione and an application thereof, a capsule thereof, and a preparation method and application of the capsule. Background technique [0002] my country is a high-incidence area of ​​viral hepatitis, among which chronic hepatitis B has attracted special attention because of its gradual development, difficulty in control, poor prognosis and complicated pathogenesis. At present, nearly 130 million people in the country are carriers of hepatitis B virus, 50 million people suffer from chronic hepatitis, and about 230,000 people die of hepatitis every year (a survey statistics from the Ministry of Health in December 2002 showed that: hepatitis It is still the infectious disease with the highest morbidity and mortality in my country), plus other known and unknown viral hepatitis diseases caused by vir...

AI Technical Summary

Problems solved by technology

However, because its active ingredients are insoluble lignans, it greatly affects the dissolution and absorption of drugs.

In the patent publication document of CN1857367, the inventor disclosed that the extract of the melon seeds containing PED I, PED II, herpetal, herpetin, herpetrione and herpetetrone was extracted from the melon seeds, but due to the limitation of the extraction process, the effective The ingredients are separated separately, so the quality of medication is not well controlled and the pertinence is not strong when treating hepatitis B.

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