Tablet capsule filled with topiramate tablets

Abstract

The invention relates to an oral hard capsule, and in particular relates to a tablet capsule filled with topiramate tablets with different specifications. The tablet capsule filled with the topiramate tablets provided by the invention comprises a capsule and tablets in the capsule, wherein the capsule comprises an upper capsule body and a lower capsule body; 2-3 tablets with the topiramate as the active ingredient are filled in the capsule; one of the topiramate tablets is of an immediate release type; and the rest of topiramate tablets are of controlled release type. The invention has the following beneficial effects that the capsule filled with the topiramate tablets with different specifications is provided; as the content tablets are different in specification and quantity, the medication requirements for different doses can be met; and as the immediate release type tablet and the controlled release type tablets are combined, the trouble of patient in taking medicine is reduced, the in-vivo concentration of the medicine is stable, the medicine within an effective concentration range is slowly released, the patient compliance is improved, and the curative effect on a disease is improved.

Description

technical field [0001] The invention relates to an oral hard capsule, in particular to a capsule filled with topiramate tablets of different specifications. Background technique [0002] Topiramate is an antiepileptic drug that is effective for all types of epilepsy, especially for primary and secondary generalized tonic-clonic seizures and simple or complex partial seizures. It is also effective for myoclonus and infantile spasms. As an adjunctive treatment of refractory seizures in adults and children, including simple partial, complex partial, and generalized tonic-clonic seizures, and seizures in myoclonic epilepsy (Lennox-Gastaut syndrome). Its pharmacological action is to selectively block voltage-dependent sodium channels. Existing topiramate products include topiramate tablets and topiramate capsules. Existing topiramate tablets have different specifications such as 25mg, 50mg, and 100mg. The surface of the tablet is coated, but it still cannot completely cover th...

AI Technical Summary

Problems solved by technology

And in the clinical trial of treating with topiramate, 200mg is the lowest dose that produces curative effect, and usual daily dose is 200~400mg, and the curative effect of topiramate is better when 400mg, and such big dosage is not very convenient with existing topiramate capsule

And the topiramate medicine in the prior art is all common release type, because topiramate can be absorbed rapidly, completely, in the course of taking medicine, if one time taking dose is bigger, can cause the concentration of topiramate in the body in a short time very big, afterwards Concentration decreases rapidly, and too high or too low drug concentration is not conducive to the control of the disease. Therefore, for topiramate, the principle of taking it in small quantities and multiple times is often used.

However, it is cumbersome to take a small amount and many times, and it is easy to forget, which reduces the patient's compliance and weakens the therapeutic effect of the disease.

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