Silicate coating-containing absorbable medical magnesium-based metal and preparation method and application thereof

A magnesium-based metal and silicate technology, which is applied in the fields of biomedical devices, orthopedic trauma surgery, medical devices for plastic surgery, repair and reconstruction surgery, can solve the problems of fast degradation speed and low surface bioactivity, and reduce the degradation speed , degradation speed and biological activity improvement, good practical effect

Inactive Publication Date: 2012-08-29
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Applying this modified coating to magnesium-based metal medical devices can solve the problems of fast degradation of absorbable medical magnesium-based metals and low surface bioactivity, and promote tissue healing at the device implantation site

Method used

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  • Silicate coating-containing absorbable medical magnesium-based metal and preparation method and application thereof
  • Silicate coating-containing absorbable medical magnesium-based metal and preparation method and application thereof
  • Silicate coating-containing absorbable medical magnesium-based metal and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Taking AZ31B (magnesium-aluminum series) magnesium alloy as the research object, the magnesium alloy was cut into Φ10×5mm samples, and finely ground with 1000# and 2000# metallographic sandpaper respectively to remove the oxide film and other impurities on the surface of the magnesium alloy . After degreasing and surface activation treatment, the magnesium alloy is ready for use.

[0042] The chemical composition and formula of the process liquid of the surface activation treatment are as follows: in the aqueous solution consisting of 200ml of glacial acetic acid, 170ml of distilled water, 8ml of nitric acid, and 0.5g of oxalic acid, the treatment temperature is room temperature, and the treatment time is 20 seconds.

[0043] Rinse the magnesium alloy after the above treatment with tap water, distilled water, absolute ethanol and distilled water in sequence, blow dry, and set aside.

[0044] The composite treatment solution is an alkaline aqueous solution containing si...

Embodiment 2

[0049] Taking ZK60 (magnesium-zinc-zirconium) magnesium alloy as the research object, the magnesium alloy is cut into Φ10×5mm samples, and finely ground with 1000# and 2000# metallographic sandpaper respectively to remove the oxide film and others on the surface of the magnesium alloy. Impurities. After degreasing and surface activation treatment, the magnesium alloy is ready for use.

[0050] The chemical composition and formula of the process treatment solution of the surface activation treatment are as follows: 300ml of glacial acetic acid, 200ml of distilled water, 15ml of nitric acid, 3g of oxalic acid in an aqueous solution, the treatment temperature is room temperature, and the treatment time is 30 seconds.

[0051] Rinse the magnesium alloy after the above treatment with tap water, distilled water, absolute ethanol and distilled water in sequence, blow dry, and set aside.

[0052] The composite treatment solution is an alkaline aqueous solution containing silicate, an...

Embodiment 3

[0056] Taking AZ31B (magnesium-aluminum series) magnesium alloy as the research object, the magnesium alloy was cut into Φ10×5mm samples, and finely ground with 1000# and 2000# metallographic sandpaper respectively to remove the oxide film and other impurities on the surface of the magnesium alloy . After degreasing and surface activation treatment, the magnesium alloy is ready for use.

[0057] The chemical composition and formula of the process treatment solution of the surface activation treatment are as follows: 100ml of glacial acetic acid, 300ml of distilled water, 30ml of nitric acid, and 8g of oxalic acid are carried out in an aqueous solution, the treatment temperature is room temperature, and the treatment time is 20 seconds.

[0058] Rinse the magnesium alloy after the above treatment with tap water, distilled water, absolute ethanol and distilled water in sequence, blow dry, and set aside.

[0059] The composite treatment solution is an alkaline aqueous solution c...

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Abstract

The invention relates to a silicate coating-containing absorbable medical magnesium-based metal, a preparation method and application thereof. The magnesium-based metal belongs to the field of biomedical appliances and is particularly suitable for the field of medical appliances used for bone trauma surgery, reparative and reconstructive surgery, and coining and cosmetology. The magnesium-based metal consists of a magnesium-based metal substrate and a silicate coating formed on the surface of the substrate, wherein the silicate coating consists of magnesium silicate (Mg2SiO4) and magnesium oxide. In an alkaline environment, a protective coating is prepared on the surface of the magnesium-based metal by a low temperature chemical deposition method. The method is simple and feasible and has low requirement on equipment; and the thickness of the coating can be controlled to be between several hundred nanometers and 5 mu m. The protective coating is uniform and dense, has high corrosion resistance, simultaneously has high biological activity and metal appearance, and can control the degradation rate of the magnesium-based metal and the dissolution rate of magnesium ions so as to control the biological activity and the absorption rate of magnesium-based metal implanted devices in organisms. The magnesium-based metal can be used for preparing intra-osteal fixing devices.

Description

technical field [0001] The invention relates to an absorbable medical magnesium-based metal containing a silicate coating and a preparation method and application thereof, belonging to the field of biomedical devices, and mainly used in the fields of orthopedic trauma surgery, repair and reconstruction surgery, and medical devices for plastic surgery. Background technique [0002] Magnesium-based metal is one of the lightest metal structural materials, and its density is very close to that of human bone (1.75g / cm 3 ), has a high specific strength, an elastic modulus of about 45GPa, and a good match between the mechanical properties and human bone tissue. Magnesium-based metals have strong activity, are very active in the body fluid environment, and are easy to corrode in the body environment, thereby achieving degradation in the body. As a degradable implant material, magnesium-based metal degrades too quickly after implantation, especially in the initial stage of implantat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/60A61L27/42A61L27/04A61L27/30A61L27/58
Inventor 王强谭丽丽张炳春杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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