The invention discloses a degradation and harmless treatment method for residual antibiotics in livestock excrement. The method comprises the following processing steps that 1, the livestock excrement enters a mixer after being preheated; 2, quicklime is put in the mixer and stirred; 3, the mixture is input into a degradation kettle, stirred and heated; 4, gas is sucked through a vacuum system when the mixture is heated; 5, gas-liquid separation is performed after the sucked gas is cooled, gas is exhausted after being irradiated through ultraviolet light and washed through a washing tower, and liquid is drained after being treated through ozone, filtered and precipitated; 6, bleaching powder saturated solutions accounting for 3%-5% of the total mass of the materials are sprayed into the degradation kettle and stirred; 7, the materials are discharged, solid-liquid separation is performed after the materials are cooled, solids are stacked for decomposition, and liquid is treated through anaerobic fermentation. The degradation and harmless treatment method for the residual antibiotics in the livestock excrement is convenient to operate, high in mechanization degree, large in treatment capacity, efficient, rapid, capable of effectively degrading and harmlessly treating the residual antibiotics in the livestock excrement and suitable for industrialization production, and meanwhile sterilization and disinfection for the livestock excrement also can be completed; after the livestock excrement is treated through the technologies, and the effects of achieving complete degradation of the residual antibiotics and being free of residues harmful to various organisms in a natural environment can be achieved.