Silver-loaded biliary tract stent with multiple layers of film coatings and preparation method of silver-loaded biliary tract stent
A multi-layer film and biliary tract technology, which is applied in the fields of coating, medical science, surgery, etc., can solve the problems such as the complexity of the preparation method of biliary tract stent, complexity, and the influence of bactericidal performance, and achieve the effect of preventing retrograde infection of biliary tract and prolonging the patency period
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Embodiment 1
[0045] (1) Preparation of chitosan-loaded nano-silver solution: First, slowly add 0.0849g of silver nitrate into 50ml of chitosan solution (pre-adjusted with HCl to pH = 3.8), and then stir evenly to obtain a chitosan solution of 10mM silver ions. Dissolve 60mg of sodium borohydride in 20ml of triple distilled water, take 5ml and slowly add the above chitosan at a rate of 0.01ml per second. After the dropwise addition, continue to stir for 0.5h, and then process the solution with a microporous membrane to remove large-sized particles and prevent particle agglomeration, and take it immediately. Ultraviolet detection was used to characterize the synthesis results of nanosilver. The prepared chitosan-loaded nano-silver solution was stored in the refrigerator in the dark, and it was detected by ultraviolet light for different days. It was found that the peak position of the nano-silver in the first 8 days basically did not move, and was stable at 396nm, indicating that the prepare...
Embodiment 2
[0048] (1) Preparation of chitosan-loaded nano-silver solution: same as in Example 1, except that the prepared chitosan-loaded nano-silver solution has a concentration of 0.01 mg / ml.
[0049] (2) Preparation of silver-loaded multilayer film-coated biliary stent: immerse the positively charged metal biliary stent in 0.01 mg / ml heparin solution for 30 minutes, wash with triple distilled water three times, and then immerse the metal biliary stent in 0.01 mg / ml chitosan Sugar-loaded nano-silver solution for 30 minutes, washed three times with triple-distilled water, and circulated the above process to obtain 20 layers of silver-loaded multilayer film-coated biliary stents arranged alternately by chitosan nano-silver layers and heparin layers. The total thickness is 100 nm.
Embodiment 3
[0051] (1) Preparation of chitosan-loaded nano-silver solution: same as in Example 1, except that the prepared chitosan-loaded nano-silver solution has a concentration of 10 mg / ml.
[0052] (2) Preparation of silver-loaded multilayer film-coated biliary stent: immerse the positively charged PET polyester biliary stent in 5 mg / ml heparin solution for 1 min after amination treatment with hexamethylenediamine small-molecule amination reagent, Wash with water three times, then immerse the PET polyester biliary stent in 10mg / ml chitosan-loaded nano-silver solution for 1min, wash with three-distilled water three times, repeat the above process, and obtain 18 layers arranged alternately by chitosan nano-silver layer and heparin layer The silver-loaded multilayer film-coated biliary stent, the total thickness of the multilayer film coating is 500nm.
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